Evidence map›Paper›PMID 28976001›Full record

ArticleJournal of cellular physiology2018

Inhibition of arterial medial calcification and bone mineralization by extracellular nucleotides: The same functional effect mediated by different cellular mechanisms.

Jessal J Patel, Dongxing Zhu, Britt Opdebeeck, Patrick D'Haese, José L Millán, Lucie E Bourne, Caroline P D Wheeler-Jones, Timothy R Arnett, Vicky E MacRae, Isabel R Orriss

Open access · greenAbstract read
In one paragraph

Article in Journal of cellular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 42 citations in OpenAlex.

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  12. A Novel 5-Chloro-Molecules (Basel, Switzerland) · 2023
    Article
  13. Article
  14. Purinergic Signaling in Oral Tissues.International journal of molecular sciences · 2022
    Review
  15. Review
  16. Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension.International journal of environmental research and public health · 2021
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Jessal J PatelDepartment of Comparative Biomedical Sciences, Royal Veterinary College, London, UK.
Dongxing ZhuGuangzhou Institute of Cardiovascular Disease, School of Basic Medical Sciences, Guangzhou Medical University, China.
Britt OpdebeeckLaboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp, Belgium.
Patrick D'HaeseLaboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp, Belgium.
José L MillánSanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
Lucie E BourneDepartment of Comparative Biomedical Sciences, Royal Veterinary College, London, UK.
Caroline P D Wheeler-JonesDepartment of Comparative Biomedical Sciences, Royal Veterinary College, London, UK.
Timothy R ArnettDepartment of Cell and Developmental Biology, University College London, London, UK.
Vicky E MacRaeThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.
Isabel R OrrissDepartment of Comparative Biomedical Sciences, Royal Veterinary College, London, UK.ORCID 0000-0002-7847-050X
Royal Veterinary College · GBUniversity of Antwerp · BEGuangzhou Medical University · CNRoslin Institute · GBSanford Burnham Prebys Medical Discovery Institute · USUniversity College London · GB

Funding

MOLECULAR PATHOGENESIS/TREATMENT OF HYPOPHOSPHATASIAR01DE012889 · NIDCR · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MILLAN, JOSE LUIS · 1999 to 2020
$9.2M
Arthritis Research UK 19205Biotechnology and Biological Sciences Research Council BB/F023928/1British Heart Foundation PG/15/13/31296NIDCR NIH HHS R01 DE012889
6 · The paper itself

Abstract

Arterial medial calcification (AMC) is thought to share some outward similarities to skeletal mineralization and has been associated with the transdifferentiation of vascular smooth muscle cells (VSMCs) to an osteoblast-like phenotype. ATP and UTP have previously been shown to inhibit bone mineralization. This investigation compared the effects of extracellular nucleotides on calcification in VSMCs with those seen in osteoblasts. ATP, UTP and the ubiquitous mineralization inhibitor, pyrophosphate (PP

Indexed as

Calcification, PhysiologicAdenosine TriphosphateAlkaline PhosphataseAnimalsApoptosisCell SurvivalDiphosphatesExtracellular SpaceMiceModels, BiologicalMuscle, Smooth, VascularMyocytes, Smooth MuscleNucleotidesOsteoblastsPhosphoric Diester HydrolasesPyrophosphatasesAdenosine TriphosphateAlkaline PhosphataseDiphosphatesdiphosphoric acidectonucleotide pyrophosphatase phosphodiesterase 1NucleotidesPhosphoric Diester HydrolasesPyrophosphatasesReceptors, Purinergic P2Uridine Triphosphatearterial medial calcificationATPbone formationNPP1vascular smooth muscle cells

Identifiers

PMID28976001
PMCPMC5792173
OpenAlexW2762302677

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.