Evidence map›Paper›PMID 28975893›Full record

ArticleeLife2017

The ESRP1-GPR137 axis contributes to intestinal pathogenesis.

Lukas Franz Mager, Viktor Hendrik Koelzer, Regula Stuber, Lester Thoo, Irene Keller, Ivonne Koeck, Maya Langenegger, Cedric Simillion, Simona P Pfister, Martin Faderl and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Intestinal Epithelial Cell-Related Alternative Splicing Events in Dextran Sodium Sulfate-Induced Acute Colitis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023
    Article
  8. Article
  9. Article
  10. Prognostic role of TSPAN1, KIAA1324 and ESRP1 in prostate cancer.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2021
    Article
  11. Article
  12. Cleft lip and cleft palate inDevelopment (Cambridge, England) · 2020
    Article
  13. Article
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 4 institutions in 2 countries.

Lukas Franz MagerInstitute of Pathology, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0002-7426-2842
Viktor Hendrik KoelzerInstitute of Pathology, University of Bern, Bern, Switzerland.
Regula StuberInstitute of Pathology, University of Bern, Bern, Switzerland.
Lester ThooInstitute of Pathology, University of Bern, Bern, Switzerland.
Irene KellerDepartment of BioMedical Research, University of Bern, Bern, Switzerland.
Ivonne KoeckInstitute of Pathology, University of Bern, Bern, Switzerland.
Maya LangeneggerInstitute of Pathology, University of Bern, Bern, Switzerland.
Cedric SimillionDepartment of BioMedical Research, University of Bern, Bern, Switzerland.
Simona P PfisterGraduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
Martin FaderlInstitute of Pathology, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0001-8807-6146
Vera GenitschInstitute of Pathology, University of Bern, Bern, Switzerland.
Irina TcymbarevichDivision of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Pascal JuilleratDepartment of Gastroenterology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Xiaohong LiCenter for Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, United States.
Yu XiaDepartment of Genetics, The Scripps Research Institute, La Jolla, United States.
Eva KaramitopoulouInstitute of Pathology, University of Bern, Bern, Switzerland.
Ruth LyckTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Inti ZlobecInstitute of Pathology, University of Bern, Bern, Switzerland.
Siegfried HapfelmeierInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.
Rémy BruggmannInterfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0003-4733-7922
Kathy D McCoyDepartment of BioMedical Research, University of Bern, Bern, Switzerland.
Andrew J MacphersonDepartment of BioMedical Research, University of Bern, Bern, Switzerland.
Christoph MüllerInstitute of Pathology, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-3921-8678
Bruce BeutlerCenter for Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, United States.
Philippe KrebsInstitute of Pathology, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0003-4918-6654
University of Bern · CHSouthwestern Medical Center · USScripps Research Institute · USUniversity Hospital of Zurich · CH

Funding

Systems Biology CoreU19AI100627 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ULEVITCH, RICHARD J · 2012 to 2021
$49.1M
Sequencing CoreP01AI070167 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI BEUTLER, BRUCE A · 2006 to 2016
$27.2M
NIAID NIH HHS P01 AI070167NIAID NIH HHS U19 AI100627
6 · The paper itself

Abstract

Aberrant alternative pre-mRNA splicing (AS) events have been associated with several disorders. However, it is unclear whether deregulated AS directly contributes to disease. Here, we reveal a critical role of the AS regulator epithelial splicing regulator protein 1 (ESRP1) for intestinal homeostasis and pathogenesis. In mice, reduced ESRP1 function leads to impaired intestinal barrier integrity, increased susceptibility to colitis and altered colorectal cancer (CRC) development. Mechanistically, these defects are produced in part by modified expression of ESRP1-specific

Indexed as

Alternative SplicingAnimalsColorectal NeoplasmsGene Expression RegulationHumansInflammatory Bowel DiseasesMiceReceptors, G-Protein-CoupledRNA-Binding ProteinsESRP1 protein, humanESRP1 protein, mouseGPR137B protein, humanReceptors, G-Protein-CoupledRNA-Binding Proteinscancer biologycell biologycolon cancerepitheliumESRP1GPR137humanintestinemousemRNA alternative splicing

Identifiers

PMID28975893
PMCPMC5665647
OpenAlexW2762667099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.