Evidence map›Paper›PMID 28975866›Full record

ArticlePharmacogenomics2017

SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria.

Vinicius A Sortica, Juliana D Lindenau, Maristela G Cunha, Maria Deise O Ohnishi, Ana Maria R Ventura, Ândrea Kc Ribeiro-Dos-Santos, Sidney Eb Santos, Luciano Sp Guimarães, Mara H Hutz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacogenomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Disease-drug and drug-drug interaction in COVID-19: Risk and assessment.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021
    Review
  4. Review
  5. Frontiers in pharmacology · 2021
    Article
  6. Quantitative Fundus Autofluorescence in HCQ Retinopathy.Investigative ophthalmology & visual science · 2020
    Observational
  7. Article
  8. Pharmacogene Variation in ThaiPharmacogenomics and personalized medicine · 2020
    Article
  9. Pharmacogenomics of COVID-19 therapies.NPJ genomic medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Vinicius A SorticaDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Juliana D LindenauDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Maristela G CunhaLaboratório de Microbiologia e Imunologia, Universidade Federal do Para, Belém, PA, Brazil.
Maria Deise O OhnishiPrograma de Ensaios Clínicos em Malária, Instituto Evandro Chagas, Sistema de Vigilância Sanitária, Ministério da Saúde, Ananindeua, PA, Brazil.
Ana Maria R VenturaPrograma de Ensaios Clínicos em Malária, Instituto Evandro Chagas, Sistema de Vigilância Sanitária, Ministério da Saúde, Ananindeua, PA, Brazil.
Ândrea Kc Ribeiro-Dos-SantosLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém, PA, Brazil.
Sidney Eb SantosLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém, PA, Brazil.
Luciano Sp GuimarãesUnidade de Bioestatística, Grupo de Pesquisa e Pós Graduação, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
Mara H HutzDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Universidade Federal do Pará · BRUniversidade Federal do Rio Grande do Sul · BRGTx (United States) · USHospital de Clínicas de Porto Alegre · BRInstituto Evandro Chagas · BRMinistério da Saúde · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe association of transporters gene polymorphisms with chloroquine/primaquine malaria treatment response was investigated in a Brazilian population. PATIENTS &

methodsTotally, 164 Plasmodium vivax malaria infected patients were included. Generalized estimating equations were performed to determine gene influences on parasitemia and/or gametocytemia clearance over treatment time.

resultsSignificant interaction between SLCO2B1 genotypes and treatment over time for parasitemia clearance rate on day 2 were observed (p

conclusionThe present work presents the first pharmacogenetic report of an association between chloroquine/primaquine responses with OATP transporters.

Indexed as

AdultAntimalarialsBrazilChloroquineDrug Therapy, CombinationFemaleGenotypeHumansLiver-Specific Organic Anion Transporter 1Malaria, VivaxMaleOrganic Anion TransportersParasitemiaPlasmodium vivaxPolymorphism, GeneticPrimaquineAntimalarialsChloroquineLiver-Specific Organic Anion Transporter 1Organic Anion TransportersPrimaquineSLCO1A2 protein, humanSLCO1B1 protein, humanSLCO2B1 protein, humanchloroquine and primaquinemalariatransporter genes

Identifiers

PMID28975866
PMCPMC7099631
OpenAlexW2762519124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.