ReviewJournal of orthopaedic research : official publication of the Orthopaedic Research Society2018
Current and novel injectable hydrogels to treat focal chondral lesions: Properties and applicability.
Review in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Bioinspired injectable hydrogels for bone regeneration.Journal of advanced research · 2025Review
- Current trends in the treatment of focal cartilage lesions: a comprehensive review.EFORT open reviews · 2025Review
- Article
- A Photopolymerizable Biocompatible Hyaluronic Acid Hydrogel Promotes Early Articular Cartilage Repair in a Minipig Model In Vivo.Advanced healthcare materials · 2023Article
- Self-healing hydrogels for bone defect repair.RSC advances · 2023Review
- Metal-Organic Frameworks (MOFs) and Their Composites as Emerging Biomaterials for Osteoarthritis Treatment.Biomimetics (Basel, Switzerland) · 2023Article
- A novel injectable fibromodulin-releasing granular hydrogel for tendon healing and functional recovery.Bioengineering & translational medicine · 2023Article
- A 3D printed mimetic composite for the treatment of growth plate injuries in a rabbit model.NPJ Regenerative medicine · 2022Article
- Recent Developments in Hyaluronic Acid-Based Hydrogels for Cartilage Tissue Engineering Applications.Polymers · 2022Review
- Dendrimer-modified gelatin methacrylate hydrogels carrying adipose-derived stromal/stem cells promote cartilage regeneration.Stem cell research & therapy · 2022Article
- An Injectable Platform of Engineered Cartilage Gel and Gelatin Methacrylate to Promote Cartilage Regeneration.Frontiers in bioengineering and biotechnology · 2022Article
- Advanced injectable hydrogels for cartilage tissue engineering.Frontiers in bioengineering and biotechnology · 2022Review
- Therapeutic application of hydrogels for bone-related diseases.Frontiers in bioengineering and biotechnology · 2022Review
- Recent Advances in Clinical Translation of Intra-Articular Osteoarthritis Drug Delivery Systems.Advanced therapeutics · 2021Article
- Synthetic alternatives to Matrigel.Nature reviews. Materials · 2020Article
- Cell encapsulation spatially alters crosslink density of poly(ethylene glycol) hydrogels formed from free-radical polymerizations.Acta biomaterialia · 2020Article
- Recent Progress in 3D Printing of Elastic and High-Strength Hydrogels for the Treatment of Osteochondral and Cartilage Diseases.Frontiers in bioengineering and biotechnology · 2020Review
- Exquisite design of injectable Hydrogels in Cartilage Repair.Theranostics · 2020Review
- Rabbit Model of Physeal Injury for the Evaluation of Regenerative Medicine Approaches.Tissue engineering. Part C, Methods · 2019Article
- Evaluation of Targeting Efficiency of Joints with Anticollagen II Antibodies.Molecular pharmaceutics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Focal chondral lesions and early osteoarthritis (OA) are responsible for progressive joint pain and disability in millions of people worldwide, yet there is currently no surgical joint preservation treatment available to fully restore the long term functionality of cartilage. Limitations of current treatments for cartilage defects have prompted the field of cartilage tissue engineering, which seeks to integrate engineering and biological principles to promote the growth of new cartilage to replace damaged tissue. Toward improving cartilage repair, hydrogel design has advanced in recent years to improve their utility. Injectable hydrogels have emerged as a promising scaffold due to their wide range of properties, the ability to encapsulate cells within the material, and their ability to provide cues for cell differentiation. Some of these advances include the development of improved control over in situ gelation (e.g., light), new techniques to process hydrogels (e.g., multi-layers), and better incorporation of biological signals (e.g., immobilization, controlled release, and tethering). This review summarises the innovative approaches to engineer injectable hydrogels toward cartilage repair. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:64-75, 2018.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.