Evidence map›Paper›PMID 28975614›Full record

ArticleEuropean journal of immunology2018

T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus.

Amandine Bovay, Vincent Zoete, Garry Dolton, Anna M Bulek, David K Cole, Pierre J Rizkallah, Anna Fuller, Konrad Beck, Olivier Michielin, Daniel E Speiser and 2 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. A Systematic, Unbiased Mapping of CD8Frontiers in immunology · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Amandine BovayDepartment of Oncology, Lausanne University Hospital (CHUV), Epalinges, Switzerland.
Vincent ZoeteSIB Swiss Institute of Bioinformatics, Molecular Modeling Group, Lausanne, Switzerland.
Garry DoltonDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff, UK.
Anna M BulekDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff, UK.
David K ColeDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff, UK.
Pierre J RizkallahDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff, UK.
Anna FullerDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff, UK.
Konrad BeckCardiff University School of Dentistry, Heath Park, Cardiff, UK.
Olivier MichielinSIB Swiss Institute of Bioinformatics, Molecular Modeling Group, Lausanne, Switzerland.
Daniel E SpeiserDepartment of Oncology, Lausanne University Hospital (CHUV), Epalinges, Switzerland.
Andrew K SewellDivision of Infection and Immunity and Systems Immunity Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff, UK.
Silvia A Fuertes MarracoDepartment of Oncology, Lausanne University Hospital (CHUV), Epalinges, Switzerland.ORCID 0000-0002-3456-3317
Institute of Infection and Immunity · CAUniversity of Lausanne · CHSIB Swiss Institute of Bioinformatics · CHCardiff University · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

The repertoire of human αβ T-cell receptors (TCRs) is generated via somatic recombination of germline gene segments. Despite this enormous variation, certain epitopes can be immunodominant, associated with high frequencies of antigen-specific T cells and/or exhibit bias toward a TCR gene segment. Here, we studied the TCR repertoire of the HLA-A*0201-restricted epitope LLWNGPMAV (hereafter, A2/LLW) from Yellow Fever virus, which generates an immunodominant CD8

Indexed as

Adaptive ImmunityCD8-Positive T-LymphocytesCell LineClonal Selection, Antigen-MediatedClone CellsComplementarity Determining RegionsCytotoxicity, ImmunologicEpitopes, T-LymphocyteHLA-A2 AntigenHumansImmunodominant EpitopesLymphocyte ActivationReceptors, Antigen, T-Cell, alpha-betaT-Cell Antigen Receptor SpecificityViral ProteinsViral VaccinesComplementarity Determining RegionsEpitopes, T-LymphocyteHLA-A*02:01 antigenHLA-A2 AntigenImmunodominant EpitopesReceptors, Antigen, T-Cell, alpha-betaViral ProteinsViral VaccinesAntigen recognitionGermlineT cell receptor Alpha Variable (TRAV)-12-2T cell receptor biasYellow Fever virus

Identifiers

PMID28975614
PMCPMC5887915
OpenAlexW2761865621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.