ArticleJournal of medical toxicology : official journal of the American College of Medical Toxicology2017
The Epidemiology, Clinical Course, and Management of Snakebites in the North American Snakebite Registry.
Article in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04996264 (Randomized, Double-Blinded, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of a Multi-Dose Regimen of Oral Varespladib-Methyl in Subjects Bitten by Venomous Snakes), which is not on this map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized, Double-Blinded, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of a Multi-Dose Regimen of Oral Varespladib-Methyl in Subjects Bitten by Venomous Snakes
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Snakebite-Associated Infections: A Systematic Review and Meta-Analysis.The American journal of tropical medicine and hygiene · 2024Pooled it
- Snakebite envenoming: A systematic review and meta-analysis of global morbidity and mortality.PLoS neglected tropical diseases · 2024Pooled it
- Antivenom Treatment Is Associated with Fewer Patients using Opioids after Copperhead Envenomation.The western journal of emergency medicine · 2019Trial
- Under pressure: Clinical management of venom-induced compartment syndrome in snakebite-A scoping review of the global literature.PLoS neglected tropical diseases · 2026Article
- Clinical epidemiology of snakebite envenoming in hospitals 11 provinces of Yangtze River Basin and southern regions of China: A retrospective hospital-based analysis.PLoS neglected tropical diseases · 2026Article
- Epidemiology of snakebite envenomation in Northwest Iran: insights from East Azerbaijan Province.BMC public health · 2026Article
- From words to worries: A cross-cultural comparison of parent-child conversations about snakes in early childhood.PloS one · 2026Article
- Comparison of Crotalidae Immune F(ab')2 (Equine) and Crotalidae Polyvalent Immune Fab (Ovine) at Establishing Control of Initial Envenomation Symptoms in Louisiana Agkistrodon Envenomations.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2025Article
- Presentation and management of snakebite envenomation at a District Hospital in the north-east of South Africa.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2025Article
- Outcomes of Copperhead Snake Envenomation Managed in a Clinical Decision Unit.The western journal of emergency medicine · 2025Article
- Analysis of Acute Hypersensitivity Reactions by Antivenom Type and Geographic Location in the North American Snake Bite Registry (NASBR).Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2025Article
- Characterization of patients with a snakebite presenting to healthcare facilities and reported to poison and drug information centers-Arizona, 2017-2021.Clinical toxicology (Philadelphia, Pa.) · 2024Article
- Treatment response and clinical features of snakebite envenomation in Alborz province, Iran: A cross-sectional study.Health science reports · 2024Article
- Efficacy and safety of two Antivenoms in the treatment of eastern copperhead (Journal of the American College of Emergency Physicians open · 2024Article
- Article
- A Case Report of Crotalidae Immune F(ab')Clinical practice and cases in emergency medicine · 2024Article
- Article
- Neurological and neuro-ophthalmological manifestations of snake bite: a systematic review.Annals of medicine and surgery (2012) · 2024Review
- Total CroFab and Anavip Antivenom Vial Administration in US Rattlesnake Envenomations: 2019-2021.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2023Article
- Delayed Recognition of Severe Systemic Envenomation after Copperhead Bite: A Case Report.Clinical practice and cases in emergency medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The American College of Medical Toxicology established the North American Snakebite Registry (NASBR), a national database of detailed, prospectively collected information regarding snake envenomation in the United States, in 2013. This report describes the epidemiology, clinical course, and management of snakebites in the NASBR. All cases entered into the NASBR between January 1, 2013 and December 31, 2015 were identified. Descriptive statistics are used to report results. Fourteen sites in 10 states entered 450 snakebites. Native species comprised 99% of cases, almost all of which were pit viper bites. 56.3% were identified as rattlesnakes and 29.4% as copperheads. 69.3% were male and 28.2% were children age 12 and under. Fifty-four percent of bites were on the lower extremity. Twenty-seven percent of patients with lower extremity bites were not wearing shoes. Common tissue findings associated with envenomation were swelling, ecchymosis, and erythema. Systemic effects and hematologic toxicity were more common in rattlesnake than copperhead or cottonmouth envenomations. Crotalidae Polyvalent Immune Fab antivenom was given to 84% of patients. Twelve patients (4.3%) were re-admitted to the hospital after completion of treatment. Eight were re-treated with antivenom. The NASBR gathers detailed data on venomous snakebites across the US. In its initial years, useful information has already been gained. Data regarding footwear will inform public health interventions and education, and information regarding the clinical presentation may help physicians better anticipate effects and manage snakebite. As the number of cases in the NASBR grows, associations between patient-related factors and outcomes may be studied.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.