Evidence map›Paper›PMID 28975422›Full record

ArticleCancer causes & control : CCC2017

Sedentary time and postmenopausal breast cancer incidence.

Sarah J O Nomura, Chiranjeev Dash, Vanessa B Sheppard, Deborah Bowen, Matthew Allison, Wendy Barrington, Rowan Chlebowski, Mace Coday, Lifang Hou, Barbara Howard and 8 more

Abstract read
In one paragraph

Article in Cancer causes & control : CCC, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Modelling the potential health and economic benefits of reducing population sitting time in Australia.The international journal of behavioral nutrition and physical activity · 2022
    Trial
  3. Article
  4. Sedentary Time and Breast Cancer Risk in the Sister Study Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sarah J O NomuraDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 1000 New Jersey Ave SE, Washington, DC, 20003, USA. sjo36@georgetown.edu.
Chiranjeev DashDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 1000 New Jersey Ave SE, Washington, DC, 20003, USA.
Vanessa B SheppardDepartment of Health Behavior and Policy, School of Medicine, Virginia Commonwealth University, 830 East Main Street, Richmond, VA, 23219, USA.
Deborah BowenDepartment of Bioethics and Humanities, University of Washington, Health Sciences Building, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
Matthew AllisonDepartment of Family Medicine and Public Health, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Wendy BarringtonDepartment of Epidemiology, School of Public Health, University of Washington, Health Sciences Building, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
Rowan ChlebowskiLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Mace CodayDepartment of Preventive Medicine, The University of Tennessee Health Science Center, Doctors Office Building, 66 North Pauline Street, Memphis, TN, 38163, USA.
Lifang HouDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 North Lake Shore Drive, Chicago, IL, 60611, USA.
Barbara HowardMedStar Health Research Institute, 6525 Belcrest Road, Hyattsville, MD, 20782, USA.
Michael LaMonteDepartment of Epidemiology and Environmental Health, University at Buffalo, 401 Kimball Tower, Buffalo, NY, 14214, USA.
JoAnn E MansonDivision of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, 900 Commonwealth Avenue, Boston, MA, 02215, USA.
Marian L NeuhouserDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109, USA.
Electra PaskettDivision of Cancer Prevention and Control, College of Medicine, The Ohio State University, 370 W 9th Ave, Columbus, OH, 43210, USA.
Maryam SattariDepartment of Internal Medicine, University of Florida College of Medicine, 2000 SW Archer Rd, Gainesville, FL, 3260, USA.
Marcia StefanickDepartment of Medicine, Stanford Prevention Research Center, Stanford University, Stanford, California, 1265 Welch Rd, Palo Alto, CA, 94305, USA.
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, University at Buffalo, 401 Kimball Tower, Buffalo, NY, 14214, USA.
Lucile L Adams-CampbellDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 1000 New Jersey Ave SE, Washington, DC, 20003, USA.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
TRAINING GRANT IN TUMOR BIOLOGYT32CA009686 · NCI · GEORGETOWN UNIVERSITY · PI ANNA Tate RIEGEL, DAVID J ROBBINS · 1996 to 2026
$10.8M
WOMENS HEALTH INITIATIVE-N01WH22110N01WH022110 · WH · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ROSS, PRENTICE · 1992 to 2006
$1.2M
Molecular Epidemiology of Oxidative Stress and Related Cancers in Black WomenK07CA197112 · NCI · GEORGETOWN UNIVERSITY · PI DASH, CHIRANJEEV · 2016 to 2020
$655k
NCATS NIH HHS UL1 TR001412NCI NIH HHS K07 CA197112NCI NIH HHS P30 CA016058NCI NIH HHS T32 CA009686NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CWHI NIH HHS N01 WH022110WHI NIH HHS N01 WH074314WHI NIH HHS N01 WH074315
6 · The paper itself

Abstract

purposeThe objective of this study was to evaluate the prospective association between sedentary time and postmenopausal breast cancer incidence, and whether associations differ by race/ethnicity, physical activity levels, and body measurements.

methodsThe Women's Health Initiative Observational Study is a prospective cohort among women ages 50-79 years at baseline (1994-1998) (analytic cohort = 70,233). Baseline questionnaire data were used to estimate time spent sitting and total sedentary time. Associations between time spent sitting and invasive breast cancer incidence overall (n = 4,115 cases through September 2015), and by hormone receptor subtypes, were investigated using Cox proportional hazards regression. Analyses were replicated stratified by race/ethnicity, body measurements, and physical activity.

resultsAmong women in this study, 34.5% reported ≤ 5 h/day sitting, 40.9% reported 6-9 h/day and 24.7% reported ≥ 10 h/day. Time spent sitting (≥ 10 vs. ≤5 h/day adjusted HR = 1.00, 95% CI 0.92-1.09) was not associated with breast cancer incidence, regardless of hormone receptor subtype. Associations did not differ by race/ethnicity, physical activity, or body measurements.

conclusionsResults from this study do not support an association between sedentary time and breast cancer incidence.

Indexed as

PostmenopauseSedentary BehaviorAgedBreast NeoplasmsEthnicityExerciseFemaleHumansIncidenceMiddle AgedProportional Hazards ModelsProspective StudiesRacial GroupsSurveys and QuestionnairesBody compositionBreast cancerPhysical activitySedentarySitting time

Identifiers

PMID28975422
PMCPMC5687985

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.