ArticleCellular and molecular life sciences : CMLS2018
The impact of thyroid hormone in seasonal breeding has a restricted transcriptional signature.
Article in Cellular and molecular life sciences : CMLS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 83 citations in OpenAlex.
- Molecular mechanisms underlying opportunistic seasonal reproduction in the male rodent pest Arvicola terrestris scherman.Scientific reports · 2026Article
- Molecular pathways affecting reproductive efficiency in seasonal breeders: prospects and implications for improving fertility in donkeys.Frontiers in veterinary science · 2025Review
- Tanycytes from a bird's eye view: gene expression profiling of the tanycytic region under different seasonal states in the Svalbard ptarmigan.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Divergence in Regulatory Regions and Gene Duplications May Underlie Chronobiological Adaptation in Desert Tortoises.Molecular ecology · 2025Article
- Characterization of theAnimal biotechnology · 2023Article
- Ambient Temperature Effects on the Spring and Autumn Somatic Growth Trajectory Show Plasticity in the Photoneuroendocrine Response Pathway in the Tundra Vole.Journal of biological rhythms · 2023Article
- Highly-Sensitive In Vitro Bioassays for FSH, TSH, PTH, Kp, and OT in Addition to LH in Mouse Leydig Tumor Cell.International journal of molecular sciences · 2023Article
- Epigenetic Regulation of miR-25 and Lnc107153 on Expression of Seasonal Estrus Key GeneBiology · 2023Article
- Day-night and seasonal variation of human gene expression across tissues.PLoS biology · 2023Article
- Exploring differentially expressed genes in hypothalamic, pars tuberalis and pineal gland transcriptomes in different sexual behavior phenotypes in rams using RNA-Seq.Journal of animal science · 2023Article
- Day-night and seasonal variation of human gene expression across tissues.bioRxiv : the preprint server for biology · 2022Article
- Photoperiods induced the circRNA differential expression in the thyroid gland of OVX+EFrontiers in endocrinology · 2022Article
- Transcriptomic Changes of Photoperiodic Response in the Hypothalamus Were Identified in Ovariectomized and Estradiol-Treated Sheep.Frontiers in molecular biosciences · 2022Article
- Antimicrobial Proteins and Peptides in Avian Eggshell: Structural Diversity and Potential Roles in Biomineralization.Frontiers in immunology · 2022Review
- Expression characteristics of pineal miRNAs at ovine different reproductive stages and the identification of miRNAs targeting the AANAT gene.BMC genomics · 2021Article
- Regional Differences in Height, Weight, and Body Composition may Result from Photoperiodic Responses: An Ecological Analysis of Japanese Children and Adolescents.Journal of circadian rhythms · 2021Article
- Identification of Photoperiod-Induced LncRNAs and mRNAs in Pituitary Pars Tuberalis of Sheep.Frontiers in veterinary science · 2021Article
- Expression analysis ofArchives animal breeding · 2020Article
- Functional Implications of RFRP-3 in the Central Control of Daily and Seasonal Rhythms in Reproduction.Frontiers in endocrinology · 2019Review
- Anti-angiogenic VEGFAxxxb transcripts are not expressed in the medio-basal hypothalamus of the seasonal sheep.PloS one · 2018Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Thyroid hormone (TH) directs seasonal breeding through reciprocal regulation of TH deiodinase (Dio2/Dio3) gene expression in tanycytes in the ependymal zone of the medio-basal hypothalamus (MBH). Thyrotropin secretion by the pars tuberalis (PT) is a major photoperiod-dependent upstream regulator of Dio2/Dio3 gene expression. Long days enhance thyrotropin production, which increases Dio2 expression and suppresses Dio3 expression, thereby heightening TH signaling in the MBH. Short days appear to exert the converse effect. Here, we combined endocrine profiling and transcriptomics to understand how photoperiod and TH control the ovine reproductive status through effects on hypothalamic function. Almost 3000 genes showed altered hypothalamic expression between the breeding- and non-breeding seasons, showing gene ontology enrichment for cell signaling, epigenetics and neural plasticity. In contrast, acute switching from a short (SP) to a long photoperiod (LP) affected the expression of a much smaller core of 134 LP-responsive genes, including a canonical group previously linked to photoperiodic synchronization. Reproductive switch-off at the end of the winter breeding season was completely blocked by thyroidectomy (THX), despite a very modest effect on the hypothalamic transcriptome. Only 49 genes displayed altered expression between intact and THX ewes, including less than 10% of the LP-induced gene set. Neuroanatomical mapping showed that many LP-induced genes were expressed in the PT, independently of the TH status. In contrast, TH-sensitive seasonal genes were principally expressed in the ependymal zone. These data highlight the distinctions between seasonal remodeling effects, which appear to be largely independent of TH, and TH-dependent localised effects which are permissive for transition to the non-breeding state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.