ArticleJournal of biomechanical engineering2018
Contractile Smooth Muscle and Active Stress Generation in Porcine Common Carotids.
Article in Journal of biomechanical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Towards the Integration of an Anti-Contractile Compound Within Drug-Coated Balloon Therapy.Cardiovascular engineering and technology · 2025Article
- Endothelial dysfunction promotes age-related reorganization of collagen fibers and alters aortic biomechanics in mice.American journal of physiology. Heart and circulatory physiology · 2025Article
- Hydrophilic Coating Microstructure Mediates Acute Drug Transfer in Drug-Coated Balloon Therapy.ACS applied bio materials · 2024Article
- Full-field strain mapping of healthy and pathological mouse aortas using stereo digital image correlation.Journal of the mechanical behavior of biomedical materials · 2023Article
- Small-diameter artery decellularization: Effects of anionic detergent concentration and treatment duration on porcine internal thoracic arteries.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Article
- Reduced Smooth Muscle Contractile Capacity Facilitates Maladaptive Arterial Remodeling.Journal of biomechanical engineering · 2022Article
- Longitudinal histomechanical heterogeneity of the internal thoracic artery.Journal of the mechanical behavior of biomedical materials · 2021Article
- The Association Between Curvature and Rupture in a Murine Model of Abdominal Aortic Aneurysm and Dissection.Experimental mechanics · 2021Article
- Diet alters age-related remodeling of aortic collagen in mice susceptible to atherosclerosis.American journal of physiology. Heart and circulatory physiology · 2021Article
- Evaluation of the Stress-Growth Hypothesis in Saphenous Vein Perfusion Culture.Annals of biomedical engineering · 2021Article
- Null strain analysis of submerged aneurysm analogues using a novel 3D stereomicroscopy device.Computer methods in biomechanics and biomedical engineering · 2020Article
- Smooth muscle regional contribution to vaginal wall function.Interface focus · 2019Article
- Comparative mechanics of diverse mammalian carotid arteries.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The mechanical response of intact blood vessels to applied loads can be delineated into passive and active components using an isometric decomposition approach. Whereas the passive response is due predominantly to the extracellular matrix (ECM) proteins and amorphous ground substance, the active response depends on the presence of smooth muscle cells (SMCs) and the contractile machinery activated within those cells. To better understand determinants of active stress generation within the vascular wall, we subjected porcine common carotid arteries (CCAs) to biaxial inflation-extension testing under maximally contracted or passive SMC conditions and semiquantitatively measured two known markers of the contractile SMC phenotype: smoothelin and smooth muscle-myosin heavy chain (SM-MHC). Using isometric decomposition and established constitutive models, an intuitive but novel correlation between the magnitude of active stress generation and the relative abundance of smoothelin and SM-MHC emerged. Our results reiterate the importance of stretch-dependent active stress generation to the total mechanical response. Overall these findings can be used to decouple the mechanical contribution of SMCs from the ECM and is therefore a powerful tool in the analysis of disease states and potential therapies where both constituent are altered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.