Evidence map›Paper›PMID 28975156›Full record

ArticleNeurology. Genetics2017

Moderate blast exposure alters gene expression and levels of amyloid precursor protein.

Jessica Gill, Ann Cashion, Nicole Osier, Lindsay Arcurio, Vida Motamedi, Kristine C Dell, Walter Carr, Hyung-Suk Kim, Sijung Yun, Peter Walker and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Jessica GillIntramural Research Program, CNRM Co Director Biomarkers Core, Uniformed Services University of the Health Sciences (J.G.) and National Institute of Nursing Research (A.C., N.O., L.A., V.M., H.-S.K., S.Y.), National Institutes of Health, Bethesda; Walter Reed Army Institute of Research (K.C.D., M.L., A.Y.), Silver Spring; Army Medical Research and Materiel Command (W.C.), Fort Detrick; and Naval Medical Research Center (P.W., S.A.), Silver Spring, MD.
Ann CashionIntramural Research Program, CNRM Co Director Biomarkers Core, Uniformed Services University of the Health Sciences (J.G.) and National Institute of Nursing Research (A.C., N.O., L.A., V.M., H.-S.K., S.Y.), National Institutes of Health, Bethesda; Walter Reed Army Institute of Research (K.C.D., M.L., A.Y.), Silver Spring; Army Medical Research and Materiel Command (W.C.), Fort Detrick; and Naval Medical Research Center (P.W., S.A.), Silver Spring, MD.
Nicole OsierIntramural Research Program, CNRM Co Director Biomarkers Core, Uniformed Services University of the Health Sciences (J.G.) and National Institute of Nursing Research (A.C., N.O., L.A., V.M., H.-S.K., S.Y.), National Institutes of Health, Bethesda; Walter Reed Army Institute of Research (K.C.D., M.L., A.Y.), Silver Spring; Army Medical Research and Materiel Command (W.C.), Fort Detrick; and Naval Medical Research Center (P.W., S.A.), Silver Spring, MD.
Lindsay ArcurioIntramural Research Program, CNRM Co Director Biomarkers Core, Uniformed Services University of the Health Sciences (J.G.) and National Institute of Nursing Research (A.C., N.O., L.A., V.M., H.-S.K., S.Y.), National Institutes of Health, Bethesda; Walter Reed Army Institute of Research (K.C.D., M.L., A.Y.), Silver Spring; Army Medical Research and Materiel Command (W.C.), Fort Detrick; and Naval Medical Research Center (P.W., S.A.), Silver Spring, MD.
Vida MotamediIntramural Research Program, CNRM Co Director Biomarkers Core, Uniformed Services University of the Health Sciences (J.G.) and National Institute of Nursing Research (A.C., N.O., L.A., V.M., H.-S.K., S.Y.), National Institutes of Health, Bethesda; Walter Reed Army Institute of Research (K.C.D., M.L., A.Y.), Silver Spring; Army Medical Research and Materiel Command (W.C.), Fort Detrick; and Naval Medical Research Center (P.W., S.A.), Silver Spring, MD.
Kristine C DellIntramural Research Program, CNRM Co Director Biomarkers Core, Uniformed Services University of the Health Sciences (J.G.) and National Institute of Nursing Research (A.C., N.O., L.A., V.M., H.-S.K., S.Y.), National Institutes of Health, Bethesda; Walter Reed Army Institute of Research (K.C.D., M.L., A.Y.), Silver Spring; Army Medical Research and Materiel Command (W.C.), Fort Detrick; and Naval Medical Research Center (P.W., S.A.), Silver Spring, MD.
Walter CarrIntramural Research Program, CNRM Co Director Biomarkers Core, Uniformed Services University of the Health Sciences (J.G.) and National Institute of Nursing Research (A.C., N.O., L.A., V.M., H.-S.K., S.Y.), National Institutes of Health, Bethesda; Walter Reed Army Institute of Research (K.C.D., M.L., A.Y.), Silver Spring; Army Medical Research and Materiel Command (W.C.), Fort Detrick; and Naval Medical Research Center (P.W., S.A.), Silver Spring, MD.
Hyung-Suk KimIntramural Research Program, CNRM Co Director Biomarkers Core, Uniformed Services University of the Health Sciences (J.G.) and National Institute of Nursing Research (A.C., N.O., L.A., V.M., H.-S.K., S.Y.), National Institutes of Health, Bethesda; Walter Reed Army Institute of Research (K.C.D., M.L., A.Y.), Silver Spring; Army Medical Research and Materiel Command (W.C.), Fort Detrick; and Naval Medical Research Center (P.W., S.A.), Silver Spring, MD.
Sijung YunIntramural Research Program, CNRM Co Director Biomarkers Core, Uniformed Services University of the Health Sciences (J.G.) and National Institute of Nursing Research (A.C., N.O., L.A., V.M., H.-S.K., S.Y.), National Institutes of Health, Bethesda; Walter Reed Army Institute of Research (K.C.D., M.L., A.Y.), Silver Spring; Army Medical Research and Materiel Command (W.C.), Fort Detrick; and Naval Medical Research Center (P.W., S.A.), Silver Spring, MD.
Peter WalkerIntramural Research Program, CNRM Co Director Biomarkers Core, Uniformed Services University of the Health Sciences (J.G.) and National Institute of Nursing Research (A.C., N.O., L.A., V.M., H.-S.K., S.Y.), National Institutes of Health, Bethesda; Walter Reed Army Institute of Research (K.C.D., M.L., A.Y.), Silver Spring; Army Medical Research and Materiel Command (W.C.), Fort Detrick; and Naval Medical Research Center (P.W., S.A.), Silver Spring, MD.
Stephen AhlersIntramural Research Program, CNRM Co Director Biomarkers Core, Uniformed Services University of the Health Sciences (J.G.) and National Institute of Nursing Research (A.C., N.O., L.A., V.M., H.-S.K., S.Y.), National Institutes of Health, Bethesda; Walter Reed Army Institute of Research (K.C.D., M.L., A.Y.), Silver Spring; Army Medical Research and Materiel Command (W.C.), Fort Detrick; and Naval Medical Research Center (P.W., S.A.), Silver Spring, MD.
Matthew LoPrestiIntramural Research Program, CNRM Co Director Biomarkers Core, Uniformed Services University of the Health Sciences (J.G.) and National Institute of Nursing Research (A.C., N.O., L.A., V.M., H.-S.K., S.Y.), National Institutes of Health, Bethesda; Walter Reed Army Institute of Research (K.C.D., M.L., A.Y.), Silver Spring; Army Medical Research and Materiel Command (W.C.), Fort Detrick; and Naval Medical Research Center (P.W., S.A.), Silver Spring, MD.
Angela YarnellIntramural Research Program, CNRM Co Director Biomarkers Core, Uniformed Services University of the Health Sciences (J.G.) and National Institute of Nursing Research (A.C., N.O., L.A., V.M., H.-S.K., S.Y.), National Institutes of Health, Bethesda; Walter Reed Army Institute of Research (K.C.D., M.L., A.Y.), Silver Spring; Army Medical Research and Materiel Command (W.C.), Fort Detrick; and Naval Medical Research Center (P.W., S.A.), Silver Spring, MD.
Walter Reed Army Institute of Research · USUnited States Army Medical Research and Development Command · US

Funding

Genomic Approaches for Elucidating Novel Targets for Pain and Symptom ManagementZIANR000015 · NINR · NATIONAL INSTITUTE OF NURSING RESEARCH · PI KIM, HYUNG SUK · 2009 to 2021
$20.2M
Biomarkers to Predict Patient Outcomes and Guide TherapiesZIANR000030 · NINR · NATIONAL INSTITUTE OF NURSING RESEARCH · PI CASHION, ANN · 2014 to 2019
$10.0M
6 · The paper itself

Abstract

objectiveTo explore gene expression after moderate blast exposure (vs baseline) and proteomic changes after moderate- (vs low-) blast exposure.

methodsMilitary personnel (N = 69) donated blood for quantification of protein level, and peak pressure exposures were detected by helmet sensors before and during a blast training program (10 days total). On day 7, some participants (n = 29) sustained a moderate blast (mean peak pressure = 7.9 psi) and were matched to participants with no/low-blast exposure during the training (n = 40). PAXgene tubes were collected from one training site at baseline and day 10; RNA-sequencing day 10 expression was compared with each participant's own baseline samples to identify genes and pathways differentially expressed in moderate blast-exposed participants. Changes in amyloid precursor protein (APP) from baseline to the day of blast and following 2 days were evaluated. Symptoms were assessed using a self-reported form.

resultsWe identified 1,803 differentially expressed genes after moderate blast exposure; the most altered network was APP. Significantly reduced levels of peripheral APP were detected the day after the moderate blast exposure and the following day. Protein concentrations correlated with the magnitude of the moderate blast exposure on days 8 and 9. APP concentrations returned to baseline levels 3 days following the blast, likely due to increases in the genetic expression of APP. Onset of concentration problems and headaches occurred after moderate blast.

conclusionsModerate blast exposure results in a signature biological profile that includes acute APP reductions, followed by genetic expression increases and normalization of APP levels; these changes likely influence neuronal recovery.

Identifiers

PMID28975156
PMCPMC5618107
OpenAlexW2760312181

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.