ArticleJournal of nephropathology2017
The protective effect of Buffalo's milk against toluene induced-nephrotoxicity in rats.
Article in Journal of nephropathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed, 12 citations in OpenAlex.
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundToluene is widely used in different activities of industrial, commercial and household applications. It can cause damage to the human body. Buffalos' milk has a good nutritive value.
objectivesThe aim of this study is to examine the negative effects of toluene on kidney tissues and to investigate the protective effects of buffalo's milk against toluene-induced nephrotoxicity in rats. MATERIALS AND
methodsForty adult male Wistar rats (180-220 g weight) were randomly assigned to eight groups (n = 5). Animals in groups I to IV received oral gavage 1 mL distilled water (DH
resultsAdministration of toluene to male rats produced dose-dependent damage in the kidney. This was noted by elevation of BUN, Cr and MDA levels. In contrast, diminished the CAT, GR and SOD enzyme activities in rats treated with toluene when compared to those in control animals. Histopathological manifestations were also observed in dose related manner in toluene-treated rats. Buffalo's milk had no effect on the biochemical parameters and kidney morphology when compared to those in control. However, it was able to prevent rat kidney against toluene toxicity.
conclusionsThe results of this study demonstrated that toluene damages kidney tissue and is a nephrotoxic substance. Buffalo's milk was able to prevent the renal damage as an antioxidant and a nephroprotective agent.
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