Evidence map›Paper›PMID 28974908›Full record

ArticleTzu chi medical journal

Association of hyperleptinemia with peripheral arterial disease in hypertensive patients.

I-Ching Huang, Chao-Chien Chang, Bang-Gee Hsu, Chung-Jen Lee, Ji-Hung Wang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tzu chi medical journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Pathophysiology of chronic peripheral ischemia: new perspectives.Therapeutic advances in chronic disease · 2020
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

I-Ching HuangSchool of Medicine, Tzu Chi University, Hualien, Taiwan.
Chao-Chien ChangSchool of Medicine, Tzu Chi University, Hualien, Taiwan.
Bang-Gee HsuSchool of Medicine, Tzu Chi University, Hualien, Taiwan.
Chung-Jen LeeDepartment of Nursing, Tzu Chi University of Science and Technology, Hualien, Taiwan.
Ji-Hung WangSchool of Medicine, Tzu Chi University, Hualien, Taiwan.
Tzu Chi University · TWBuddhist Tzu Chi General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHypertension is a risk factor for peripheral artery disease (PAD). Serum leptin plays an important role in promoting endothelial dysfunction. The aim of this study is to investigate whether the leptin level is associated with PAD in hypertensive patients. MATERIALS AND

methodsNinety-eight hypertensive patients were enrolled in this study. Ankle-brachial index (ABI) values were measured using an automated oscillometric device. Patients with an ABI value <0.9 were considered the low ABI group. C-reactive protein (CRP) was measured using standard enzymatic automated methods. Serum levels of human leptin were determined using a commercially available enzyme immunoassay.

resultsEighteen (18.4%) hypertensive patients were included in the low ABI group. Hypertensive patients in the low ABI group had higher serum creatinine (

conclusionA higher log-leptin value is an independent predictor of PAD in hypertensive patients.

Indexed as

Ankle-brachial indexHypertensionLeptinPeripheral arterial disease

Identifiers

PMID28974908
PMCPMC5615994
OpenAlexW2754952459

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.