ArticleWorld journal of gastroenterology2017
Systemic immune-inflammation index for predicting prognosis of colorectal cancer.
Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07544719 (Prognostic Value of Systemic Immun Inflamation Index in Geriatrik Patient Admitted to the ICU After Surgery), which is not on this map. Cited by 462 papers, 9 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prognostic Value of Systemic Immun Inflamation Index in Geriatrik Patient Admitted to the ICU After Surgery: A Prospective Observational Study
Who cites it
462 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Prognostic significance of systemic immune-inflammation index in hepatocellular carcinoma: a meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Pooled it
- Prognostic Role of Blood Inflammatory Composite Biomarkers in Dvt After Lower Extremity Fractures.The Iowa orthopaedic journal · 2026Pooled it
- Prognostic value of systemic immune-inflammation index for colorectal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Preoperative neutrophil-to-lymphocyte ratio and systemic immune-inflammation index as prognostic biomarkers for postoperative pneumonia and pulmonary complications after thoracic surgery: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Prognostic value and clinicopathological significance of pre-and post-treatment systemic immune-inflammation index in colorectal cancer patients: a meta-analysis.World journal of surgical oncology · 2025Pooled it
- Predictive value of systemic immune-inflammation index in patients with diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Inflammation and Colorectal Cancer: A Meta-Analysis of the Prognostic Significance of the Systemic Immune-Inflammation Index (SII) and the Systemic Inflammation Response Index (SIRI).International journal of molecular sciences · 2024Pooled it
- Plasma 25-hydroxyvitamin D deficiency in the peri-operative period is associated with survival outcome in colorectal cancer patients: a meta-analysis.BMC surgery · 2024Pooled it
- Predictive value of NLR and PLR for immune-related adverse events: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Pooled it
- Trial
- Trial
- Machine learning-based prediction of intraoperative blood transfusion in major surgery: exploiting clinical variables and systemic inflammatory indices.Annals of medicine · 2026Article
- Article
- Association between tooth loss and kidney function: indirect roles of oxidative stress and systemic inflammation in NHANES 2001-2020.The Saudi dental journal · 2026Article
- Cancer risk and mortality assessment in the overweight population: evaluation of single and integrated models based on inflammatory markers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Dual-center development and validation of an immunoinflammatory-based preoperative model for predicting postoperative cachexia in colorectal cancer.Updates in surgery · 2026Article
- Observational
- Systemic immune-inflammation index as a risk factor for acute kidney injury in patients with neonatal jaundice.Translational pediatrics · 2026Article
- Respiratory Versus Gastrointestinal Malignancies: Systemic Inflammation, Cardiovascular Burden, and All-Cause Mortality.Journal of clinical medicine · 2026Article
- Integrated assessment of preoperative nutritional, inflammatory, and metabolic biomarkers and early outcomes in geriatric hip fracture surgery: a retrospective matched study.BMC geriatrics · 2026Article
402 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the clinical significance of preoperative systemic immune-inflammation index (SII) in patients with colorectal cancer (CRC).
methodsA retrospective analysis of 1383 cases with CRC was performed following radical surgery. SII was calculated with the formula SII = (P × N)/L, where P, N, and L refer to peripheral platelet, neutrophil, and lymphocyte counts, respectively. The clinicopathological features and follow-up data were evaluated to compare SII with other systemic inflammation-based prognostic indices such as the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in patients with CRC.
resultsThe optimal cut-off point for SII was defined as 340. The overall survival (OS) and disease-free survival (DFS) were better in patients with low NLR, PLR, and SII (
conclusionSII is a more powerful tool for predicting survival outcome in patients with CRC. It might assist the identification of high-risk patients among patients with the same TNM stage.
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