ArticleScientific reports2017
Maternal Smoking in Pregnancy and Offspring Depression: a cross cohort and negative control study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The Impact of Maternal Smoking During Pregnancy on Depressive and Anxiety Behaviors in Offspring: A Meta-analysis.Depression and anxiety · 2025Pooled it
- The impact of paternal alcohol, tobacco, caffeine use and physical activity on offspring mental health: a systematic review and meta-analysis.Reproductive health · 2021Pooled it
- Research Review: Developmental origins of depression - a systematic review and meta-analysis.Journal of child psychology and psychiatry, and allied disciplines · 2021Pooled it
- Environmental Risk Factors and Health: An Umbrella Review of Meta-Analyses.International journal of environmental research and public health · 2021Pooled it
- Prenatal tobacco use and the risk of mood disorders in offspring: a systematic review and meta-analysis.Social psychiatry and psychiatric epidemiology · 2020Pooled it
- Exploring parental prenatal influences on child health: A multicohort study and data visualisation tool.PLoS medicine · 2026Article
- Maternal smoking during pregnancy in relation to adolescent anxiety and poor mental health: A cross-sectional study based on NHANES 2007-2012.Tobacco induced diseases · 2026Article
- Maternal immune-mediated conditions and ADHD risk in offspring.BMC medicine · 2025Article
- Article
- Proxy gene-by-environment Mendelian randomization study of the association between cigarette smoking during pregnancy and offspring mental health.International journal of epidemiology · 2023Article
- Deriving GWAS summary estimates for paternal smoking in UK biobank: a GWAS by subtraction.BMC research notes · 2023Article
- Mental health among bereaved youth in the ALSPAC birth cohort: Consideration of early sociodemographic precursors, cognitive ability, and type of loss.Development and psychopathology · 2023Article
- Maternal smoking around birth may lower the protective effects of breastfeeding on anxiety, depression and neuroticism in adult offspring: a UK biobank study.European archives of psychiatry and clinical neuroscience · 2023Article
- Complete case logistic regression with a dichotomised continuous outcome led to biased estimates.Journal of clinical epidemiology · 2023Article
- Association of maternal polygenic risk scores for mental illness with perinatal risk factors for offspring mental illness.Science advances · 2022Article
- Prenatal smoking, alcohol and caffeine exposure and maternal-reported attention deficit hyperactivity disorder symptoms in childhood: triangulation of evidence using negative control and polygenic risk score analyses.Addiction (Abingdon, England) · 2022Article
- Maternal and child genetic liability for smoking and caffeine consumption and child mental health: an intergenerational genetic risk score analysis in the ALSPAC cohort.Addiction (Abingdon, England) · 2021Article
- Prevalence and contributory factors of anxiety and depression among pregnant women in the post-pandemic era of COVID-19 in Shenzhen, China.Journal of affective disorders · 2021Article
- Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health.International journal of epidemiology · 2020Article
- Prenatal risk factors for internalizing and externalizing problems in childhood.World journal of pediatrics : WJP · 2020Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Previous reports suggest that offspring of mothers who smoke during pregnancy have greater risk of developing depression. However, it is unclear whether this is due to intrauterine effects. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) from the UK (N = 2,869), the Nord-Trøndelag health study (HUNT) from Norway (N = 15,493), the Pelotas 1982 Birth Cohort Study from Brazil (N = 2,626), and the Swedish Sibling Health Cohort (N = 258 sibling pairs), we compared associations of maternal smoking during pregnancy and mother's partner's smoking during pregnancy with offspring depression and performed a discordant sibling analysis. In meta-analysis, maternal smoking during pregnancy was associated with higher odds of offspring depression (OR 1.20, 95% CI:1.08,1.34), but mother's partner's smoking during pregnancy was not (OR 1.05, 95% CI:0.94,1.17). However, there was only weak statistical evidence that the odds ratios for maternal and mother's partner's smoking differed from each other (p = 0.08). There was no clear evidence for an association between maternal smoking during pregnancy and offspring depression in the sibling analysis. Findings do not provide strong support for a causal role of maternal smoking during pregnancy in offspring depression, rather observed associations may reflect residual confounding relating to characteristics of parents who smoke.
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