Evidence map›Paper›PMID 28974642›Full record

ArticleDevelopment (Cambridge, England)2017

An essential role for IGF2 in cartilage development and glucose metabolism during postnatal long bone growth.

Tomoya Uchimura, Judith M Hollander, Daisy S Nakamura, Zhiyi Liu, Clifford J Rosen, Irene Georgakoudi, Li Zeng

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
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  13. Association ofMolecular genetics and metabolism reports · 2024
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  15. Humero-femoral index and diabetes risk in the US population- a case study.Journal of diabetes and metabolic disorders · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tomoya UchimuraProgram in Cell, Molecular and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA.
Judith M HollanderProgram in Cell, Molecular and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA.
Daisy S NakamuraProgram in Cell, Molecular and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA.
Zhiyi LiuDepartment of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA.
Clifford J RosenCenter for Clinical & Translational Research, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA.
Irene GeorgakoudiDepartment of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA.
Li ZengProgram in Cell, Molecular and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA li.zeng@tufts.edu.ORCID 0000-0003-3720-5168
Tufts University · USMaine Medical Center Research Institute · US

Funding

Tufts Clinical and Translational Research InstituteUL1TR001064 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2013 to 2017
$26.4M
Osteoblastic Respiration and IRS SignalingR21AR066120 · NIAMS · MAINEHEALTH · PI ROSEN, CLIFFORD JAMES · 2015 to 2016
$411k
Screening antibiotics using NIR fluorescence imaging for osteoarthritis treatmentR21AR069278 · NIAMS · TUFTS UNIVERSITY BOSTON · PI ZENG, LI · 2016 to 2017
$399k
Nkx3.2 nuclear localization and cartlidge formationR03AR054611 · NIAMS · TUFTS UNIVERSITY BOSTON · PI ZENG, LI · 2007 to 2009
$242k
NCATS NIH HHS UL1 TR001064NIAMS NIH HHS R03 AR054611NIAMS NIH HHS R21 AR066120NIAMS NIH HHS R21 AR069278
6 · The paper itself

Abstract

Postnatal bone growth involves a dramatic increase in length and girth. Intriguingly, this period of growth is independent of growth hormone and the underlying mechanism is poorly understood. Recently, an

Indexed as

ChondrogenesisAnimalsAnimals, NewbornBone DevelopmentCartilageCell DifferentiationChondrocytesGene Expression Regulation, DevelopmentalGlucoseGlycolysisGrowth PlateHypertrophyInsulin-Like Growth Factor IIMiceModels, BiologicalMutationGlucoseInsulin-Like Growth Factor IICartilageEndochondral ossificationGlucose metabolismGrowth plateIGF2Postnatal

Identifiers

PMID28974642
PMCPMC5665487
OpenAlexW2763411561

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.