Evidence map›Paper›PMID 28974549›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

Modulation of Navitoclax Sensitivity by Dihydroartemisinin-Mediated MCL-1 Repression in BCR-ABL

Amit Budhraja, Meghan E Turnis, Michelle L Churchman, Anisha Kothari, Xue Yang, Haiyan Xu, Ewa Kaminska, John C Panetta, David Finkelstein, Charles G Mullighan and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

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  20. Antitumor Research on Artemisinin and Its Bioactive Derivatives.Natural products and bioprospecting · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Amit BudhrajaDepartment of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Meghan E TurnisDepartment of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Michelle L ChurchmanDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Anisha KothariDepartment of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Xue YangDepartment of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Haiyan XuDepartment of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Ewa KaminskaDepartment of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
John C PanettaDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee.
David FinkelsteinDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Charles G MullighanDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Joseph T OpfermanDepartment of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee. Joseph.Opferman@stjude.org.
St. Jude Children's Research Hospital · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Regulation of Cell Death and Mitochondrial Physiology by Anti-Apoptotic MCL-1R01HL102175 · NHLBI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI OPFERMAN, JOSEPH T. · 2010 to 2014
$2.1M
Pathway Specific Combinational Therapy in Poor Prognosis B-Lineage Acute Lymphoblastic LeukemiaR01CA201069 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI OPFERMAN, JOSEPH T. · 2016 to 2020
$2.0M
NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA201069NHLBI NIH HHS R01 HL102175
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Aniline CompoundsFusion Proteins, bcr-ablLeukemia, B-CellMyeloid Cell Leukemia Sequence 1 ProteinPrecursor Cell Lymphoblastic Leukemia-LymphomaSulfonamidesAnimalsAntineoplastic Combined Chemotherapy ProtocolsApoptosisArtemisininsCell Line, TumorDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHumansMiceProto-Oncogene Proteins c-bcl-2Aniline CompoundsArtemisininsartenimolFusion Proteins, bcr-ablMCL1 protein, humanMyeloid Cell Leukemia Sequence 1 ProteinnavitoclaxProto-Oncogene Proteins c-bcl-2Sulfonamides

Identifiers

PMID28974549
PMCPMC5786379
OpenAlexW2761923752

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.