Evidence map›Paper›PMID 28974519›Full record

ArticleCirculation2017

Delayed Repolarization Underlies Ventricular Arrhythmias in Rats With Heart Failure and Preserved Ejection Fraction.

Jae Hyung Cho, Rui Zhang, Peter J Kilfoil, Romain Gallet, Geoffrey de Couto, Catherine Bresee, Joshua I Goldhaber, Eduardo Marbán, Eugenio Cingolani

Open access · bronzeAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
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  4. Effects of a postnatal high-salt diet on cardiac function in offspring from hypoxic pregnancies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Jae Hyung ChoCedars-Sinai Heart Institute, Los Angeles, CA (J.H.C., R.Z., P.J.K., G.d.C., J.I.G., E.M., E.C.).
Rui ZhangCedars-Sinai Heart Institute, Los Angeles, CA (J.H.C., R.Z., P.J.K., G.d.C., J.I.G., E.M., E.C.).
Peter J KilfoilCedars-Sinai Heart Institute, Los Angeles, CA (J.H.C., R.Z., P.J.K., G.d.C., J.I.G., E.M., E.C.).
Romain GalletHenri Mondor University Hospital, Créteil, France (R.G.).
Geoffrey de CoutoCedars-Sinai Heart Institute, Los Angeles, CA (J.H.C., R.Z., P.J.K., G.d.C., J.I.G., E.M., E.C.).
Catherine BreseeBiostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, CA (C.B.).
Joshua I GoldhaberCedars-Sinai Heart Institute, Los Angeles, CA (J.H.C., R.Z., P.J.K., G.d.C., J.I.G., E.M., E.C.).
Eduardo MarbánCedars-Sinai Heart Institute, Los Angeles, CA (J.H.C., R.Z., P.J.K., G.d.C., J.I.G., E.M., E.C.) eduardo.marban@csmc.edu eugenio.cingolani@csmc.edu.
Eugenio CingolaniCedars-Sinai Heart Institute, Los Angeles, CA (J.H.C., R.Z., P.J.K., G.d.C., J.I.G., E.M., E.C.) eduardo.marban@csmc.edu eugenio.cingolani@csmc.edu.
Cedars-Sinai Smidt Heart Institute · USHôpitaux Universitaires Henri-Mondor · FR

Funding

Training in Advanced Heart Disease ResearchT32HL116273 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Joshua I Goldhaber, EDUARDO MARBAN · 2013 to 2026
$5.6M
Exosome-mediated cardioprotection and regenerationR01HL124074 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI MARBAN, EDUARDO · 2014 to 2021
$4.0M
Biological pacemaker from proof-of-concept to clinicR01HL135866 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CINGOLANI, EUGENIO, GOLDHABER, JOSHUA I · 2017 to 2020
$3.2M
NHLBI NIH HHS R01 HL124074NHLBI NIH HHS R01 HL135866NHLBI NIH HHS T32 HL116273
6 · The paper itself

Abstract

backgroundHeart failure with preserved ejection fraction (HFpEF) represents approximately half of heart failure, and its incidence continues to increase. The leading cause of mortality in HFpEF is sudden death, but little is known about the underlying mechanisms.

methodsDahl salt-sensitive rats were fed a high-salt diet (8% NaCl) from 7 weeks of age to induce HFpEF (n=38). Rats fed a normal-salt diet (0.3% NaCl) served as controls (n=13). Echocardiograms were performed to assess systolic and diastolic function from 14 weeks of age. HFpEF-verified and control rats underwent programmed electrical stimulation. Corrected QT interval was measured by surface ECG. The mechanisms of ventricular arrhythmias (VA) were probed by optical mapping, whole-cell patch clamp to measure action potential duration and ionic currents, and quantitative polymerase chain reaction and Western blotting to investigate changes in ion channel expression.

resultsAfter 7 weeks of a high-salt diet, 31 of 38 rats showed diastolic dysfunction and preserved ejection fraction along with signs of heart failure and hence were diagnosed with HFpEF. Programmed electric stimulation demonstrated increased susceptibility to VA in HFpEF rats (

conclusionsSusceptibility to VA was markedly increased in rats with HFpEF. Underlying abnormalities include QT prolongation, delayed repolarization from downregulation of potassium currents, and multiple reentry circuits during VA. Our findings are consistent with the hypothesis that potassium current downregulation leads to abnormal repolarization in HFpEF, which in turn predisposes to VA and sudden cardiac death.

Indexed as

Action PotentialsHeart RateVentricular Function, LeftAnimalsArrhythmias, CardiacCardiac Pacing, ArtificialDisease Models, AnimalElectrocardiographyFibrosisHeart FailureHeart VentriclesIsolated Heart PreparationMalePatch-Clamp TechniquesPotassiumRats, Inbred DahlKcnd3 protein, ratPotassiumShal Potassium ChannelsSodium Chloride, Dietaryaction potentialsarrhythmias, cardiacdeath, suddenfibrosisheart failurepatch-clamp techniquespotassium channels

Identifiers

PMID28974519
PMCPMC5698112
OpenAlexW2762062721

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.