ArticleBlood2017
Hematopoietic stem cell transplantation rescues the hematological, immunological, and vascular phenotype in DADA2.
Abstract readMulticenter Study
In one paragraph
Article in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A wide spectrum of phenotype of deficiency of deaminase 2 (DADA2): a systematic literature review.Orphanet journal of rare diseases · 2023Pooled it
- ADA2 genotype and enzyme activity may predict vasculitic or hematologic DADA2 phenotype.Journal of human immunity · 2026Article
- Adenosine deaminase type 2 deficiency: From rare to common.Journal of human immunity · 2026Review
- DADA2 as a Model of Monogenic Immune Vasculopathy: From Immunopathogenesis to Precision Therapeutics.Biomolecules · 2026Review
- ADA2-deficient cells exhibit increased levels of cell death and metabolic disturbances.Cell death discovery · 2026Article
- A Review of Adenosine Deaminase 2 (ADA2) as a Biomarker of Monocyte/Macrophage Activation.Current allergy and asthma reports · 2026Review
- Mechanisms outpacing medicine in autoinflammatory diseases.Frontiers in immunology · 2026Review
- Gene therapy supports long-term reconstitution of patient hematopoietic stem cells in deficiency of adenosine deaminase 2.Molecular therapy. Methods & clinical development · 2025Article
- Preclinical evaluation of lentiviral gene therapy for adenosine deaminase 2 deficiency (DADA2): engraftment efficiency and biodistribution in humanised NBSGW mice.Gene therapy · 2025Article
- Dominant negative ADA2 mutations cause ADA2 deficiency in heterozygous carriers.The Journal of experimental medicine · 2025Article
- Inhibition of lysosomal degradation increases expression of mutant ADA2 in DADA2 monocytes.The Journal of allergy and clinical immunology · 2025Article
- GroβT rapidly and reliably mobilizes primitive hematopoietic stem and progenitor cells in nonhuman primates.Molecular therapy. Methods & clinical development · 2025Article
- The pathogenesis of cerebral small vessel disease and vascular cognitive impairment.Physiological reviews · 2025Review
- Getting to know adenosine deaminase 2 deficiency inside and out.The Journal of allergy and clinical immunology · 2025Review
- A Clinical Case Report of Deficiency of Adenosine Deaminase 2 Syndrome (DADA 2) Presenting as a Brachial Artery Aneurysm.Mediterranean journal of rheumatology · 2025Article
- Early bone marrow alterations in patients with adenosine deaminase 2 deficiency across disease phenotypes and severities.The Journal of allergy and clinical immunology · 2025Article
- Human ADA2 Deficiency: Ten Years Later.Current allergy and asthma reports · 2024Review
- Genetic Testing in Patients with Autoimmune Lymphoproliferative Syndrome: Experience of 802 Patients at Cincinnati Children's Hospital Medical Center.Journal of clinical immunology · 2024Article
- Genetic Evaluation of the Patients with Clinically Diagnosed Inborn Errors of Immunity by Whole Exome Sequencing: Results from a Specialized Research Center for Immunodeficiency in Türkiye.Journal of clinical immunology · 2024Article
- ADA2 regulates inflammation and hematopoietic stem cell emergence via the ACommunications biology · 2024Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
22 authors.
Hasan HashemDivision of Pediatric Bone Marrow Transplantation, Nationwide Children's Hospital, Ohio State University, Columbus, OH.
Ashish R KumarDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Ingo MüllerDivision of Pediatric Stem Cell Transplant and Immunology, University Medical Center of Hamburg-Eppendorf, Hamburg, Germany.
Florian BaborDepartment of Hematology, Oncology and Clinical Immunology, Center for Child and Adolescent Health, University of Duesseldorf, Duesseldorf, Germany.
Robbert BrediusDepartment of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
Jignesh DalalDivision of Pediatric Bone Marrow Transplant, Rainbow Babies and Children's Hospital, Cleveland, OH.
Amy P HsuLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, and.
Steven M HollandLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, and.
Dennis D HicksteinExperimental Transplantation and Immunology, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Stephen JollesImmunodeficiency Center for Wales, University Hospital of Wales, Cardiff, United Kingdom.
Robert KranceCell and Gene Therapy, Baylor College of Medicine, Houston, TX.
Ghadir SasaCell and Gene Therapy, Baylor College of Medicine, Houston, TX.
Mervi TaskinenDivision of Pediatric Hematology, Oncology and Stem Cell Transplantation, Helsinki University Hospital, and.
Minna KoskenvuoDivision of Pediatric Hematology, Oncology and Stem Cell Transplantation, Helsinki University Hospital, and.
Janna SaarelaInstitute for Molecular Medicine, University of Helsinki, Helsinki, Finland.
Joris van MontfransDivision of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Center of Utrecht, Utrecht, The Netherlands.
Keith WilsonDepartment of Hematology, University Hospital of Wales, Cardiff, United Kingdom.
Barbara BoschDepartment of Pediatrics, Division of Immunology, University Hospitals of Leuven, Leuven, Belgium.
Leen MoensDepartment of Pediatrics, Division of Immunology, University Hospitals of Leuven, Leuven, Belgium.
Michael HershfieldDepartment of Medicine and Biochemistry, Duke University Medical Center, Durham, NC.
Isabelle MeytsDepartment of Pediatrics, Division of Immunology, University Hospitals of Leuven, Leuven, Belgium.
Deficiency of Adenosine Deaminase Type 2 Foundation
Funding
Genes And Gene Products As ImmunoadjuvantsZIAAI000647 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.6MAbstract
Deficiency of adenosine deaminase 2 (DADA2) is caused by biallelic deleterious mutations in
Indexed as
MutationAdenosine DeaminaseAdolescentChildChild, PreschoolCohort StudiesFemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansImmunologic Deficiency SyndromesInfantInfant, NewbornIntercellular Signaling Peptides and ProteinsMalePhenotypeADA2 protein, humanAdenosine DeaminaseIntercellular Signaling Peptides and Proteins
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Textmetadata
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.