Evidence map›Paper›PMID 28974480›Full record

Trial reportEnvironmental health perspectives2017

Plasma Concentrations of Per- and Polyfluoroalkyl Substances at Baseline and Associations with Glycemic Indicators and Diabetes Incidence among High-Risk Adults in the Diabetes Prevention Program Trial.

Andres Cardenas, Diane R Gold, Russ Hauser, Ken P Kleinman, Marie-France Hivert, Antonia M Calafat, Xiaoyun Ye, Thomas F Webster, Edward S Horton, Emily Oken

Open access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Environmental health perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 3 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 3 syntheses or guidelines pooled it, 146 citations in OpenAlex.

  1. Pooled it
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  19. Perfluorooctanoic acid disrupts hepatic metabolism in the developing chicken embryo.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Andres CardenasDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim HealthCare Institute , Boston, Massachusetts, USA.
Diane R GoldChanning Laboratory, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Russ HauserDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Ken P KleinmanDepartment of Biostatistics, School of Public Health and Human Sciences, University of Massachusetts Amherst , Amherst, Massachusetts, USA.
Marie-France HivertDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim HealthCare Institute , Boston, Massachusetts, USA.
Antonia M CalafatDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention , Atlanta, Georgia, USA.
Xiaoyun YeDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention , Atlanta, Georgia, USA.
Thomas F WebsterDepartment of Environmental Health, Boston University School of Public Health , Boston, Massachusetts, USA.
Edward S HortonJoslin Diabetes Center, Harvard Medical School , Boston, Massachusetts, USA.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim HealthCare Institute , Boston, Massachusetts, USA.
Harvard University · USCenters for Disease Control and Prevention · USBoston University · USBrigham and Women's Hospital · USJoslin Diabetes Center · USUniversity of Massachusetts Amherst · US

Funding

Long-term prospective associations of PFAS with musculoskeletal and cardiovascular health among older adultsR01ES024765 · NIEHS · HARVARD PILGRIM HEALTH CARE, INC. · PI Abby Fleisch, Emily Oken · 2015 to 2026
$3.9M
Patient-oriented Research in Maternal Perinatal Overnutrition and Child AdiposityK24HD069408 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2011 to 2015
$844k
NICHD NIH HHS K24 HD069408NIEHS NIH HHS R01 ES024765
6 · The paper itself

Abstract

backgroundSeveral per- and polyfluoroalkyl substances (PFAS) are ubiquitous anthropogenic pollutants almost universally detected in humans. Experimental evidence indicates that PFAS alter glucose metabolism and insulin secretion. However, epidemiological studies have yielded inconsistent results.

objectiveWe sought to examine associations between plasma PFAS concentrations, glycemic indicators, and diabetes incidence among high-risk adults.

methodsWithin the Diabetes Prevention Program (DPP), a trial for the prevention of type 2 diabetes among high-risk individuals, we quantified baseline plasma concentrations of nine PFAS among 957 participants randomized to a lifestyle intervention or placebo. We evaluated adjusted associations for plasma PFAS concentrations with diabetes incidence and key glycemic indicators measured at baseline and annually over up to 4.6 y.

resultsPlasma PFAS concentrations were similar to those reported in the U.S. population in 1999-2000. At baseline, in cross-sectional analysis, a doubling in plasma perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) concentrations was associated with higher homeostatic model assessment of insulin resistance (HOMA-IR) [β

conclusionsAt baseline, several PFAS were cross-sectionally associated with small differences in markers of insulin secretion and β-cell function. However, there was limited evidence suggesting that PFAS concentrations are associated with diabetes incidence or changes in glycemic indicators during the follow-up period. https://doi.org/10.1289/EHP1612.

Indexed as

AdultAlkanesulfonic AcidsBlood GlucoseCaprylatesDiabetes Mellitus, Type 2Environmental ExposureEnvironmental PollutantsFluorocarbonsHumansIncidenceAlkanesulfonic AcidsBlood GlucoseCaprylatesEnvironmental PollutantsFluorocarbonsperfluorooctane sulfonic acidperfluorooctanoic acid

Identifiers

PMID28974480
PMCPMC5933403
OpenAlexW2762019316

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.