Evidence map›Paper›PMID 28974225›Full record

ReviewJournal of nanobiotechnology2017

Metal nanoparticles: understanding the mechanisms behind antibacterial activity.

Yael N Slavin, Jason Asnis, Urs O Häfeli, Horacio Bach

Open access · goldAbstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 643 papers.

0numbers the graph read from it
0cells of the map it votes in
643citing papers in PubMed
49.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

643 citing papers in PubMed, 2,425 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Green Synthesis and Characterization of SiOApplied biochemistry and biotechnology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Eco-Friendly Synthesis of Silver Nanoparticles UsingInternational journal of molecular sciences · 2026
    Article
  16. Review
  17. Review
  18. Bioactive Silver Nanoparticles Synthesized Using EndophyticPharmaceuticals (Basel, Switzerland) · 2026
    Article
  19. Article
  20. Synthesis of Silver Phosphate (AgInternational journal of molecular sciences · 2026
    Article

583 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yael N SlavinDepartment of Medicine, Division of Infectious Diseases, University of British Columbia, 410-2660 Oak St., Vancouver, BC, V6H3Z6, Canada.
Jason AsnisFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
Urs O HäfeliFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
Horacio BachDepartment of Medicine, Division of Infectious Diseases, University of British Columbia, 410-2660 Oak St., Vancouver, BC, V6H3Z6, Canada. hbach@mail.ubc.ca.
University of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action. The continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. Metal NPs are among the most promising of these because show strong antibacterial activity. This review summarizes and discusses proposed mechanisms of antibacterial action of different metal NPs. These mechanisms of bacterial killing include the production of reactive oxygen species, cation release, biomolecule damages, ATP depletion, and membrane interaction. Finally, a comprehensive analysis of the effects of NPs on the regulation of genes and proteins (transcriptomic and proteomic) profiles is discussed.

Indexed as

AnimalsAnti-Bacterial AgentsBacteriaBacterial InfectionsBacterial ProteinsGene Expression Regulation, BacterialHumansMetal NanoparticlesProteomicsReactive Oxygen SpeciesTranscriptomeAnti-Bacterial AgentsBacterial ProteinsReactive Oxygen SpeciesAntibacterial resistanceBacteriaGene regulationMechanism of defenseMetalsNanoparticlesProteomicsROSTranscriptomics

Identifiers

PMID28974225
PMCPMC5627441
OpenAlexW2760892774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.