ArticleJournal of neurotrauma2018
The Relationship between Lesion Severity Characterized by Diffusion Tensor Imaging and Motor Function in Chronic Canine Spinal Cord Injury.
Article in Journal of neurotrauma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Predictive value of dynamic diffusion tensor imaging for surgical outcomes in patients with cervical spondylotic myelopathy.BMC medical imaging · 2024Article
- Efficacy of Medical Ozone as an Adjuvant Treatment in Dogs with Intervertebral Disc Protusions-A Retrospective Study.Animals : an open access journal from MDPI · 2023Article
- Changes and clinical correlation of diffusion tensor imaging parameters of compressed spinal cord and nerve root in patients with cervical spondylosis.BMC medical imaging · 2022Article
- Diffusion tensor imaging-based quantitative analysis of the spinal cord in Pembroke Welsh Corgis with degenerative myelopathy.The Journal of veterinary medical science · 2022Article
- Not all voxels are created equal: Reducing estimation bias in regional NODDI metrics using tissue-weighted means.NeuroImage · 2021Article
- Nervous system modulation through electrical stimulation in companion animals.Acta veterinaria Scandinavica · 2021Review
- In vivo detection of microstructural spinal cord lesions in dogs with degenerative myelopathy using diffusion tensor imaging.Journal of veterinary internal medicine · 2021Article
- Magnetization transfer and diffusion tensor imaging in dogs with intervertebral disk herniation.Journal of veterinary internal medicine · 2020Article
- Association between anesthesia duration and outcome in dogs with surgically treated acute severe spinal cord injury caused by thoracolumbar intervertebral disk herniation.Journal of veterinary internal medicine · 2020Article
- Prognostic Factors in Canine Acute Intervertebral Disc Disease.Frontiers in veterinary science · 2020Review
- Diagnostic Imaging in Intervertebral Disc Disease.Frontiers in veterinary science · 2020Review
- Ambulation in Dogs With Absent Pain Perception After Acute Thoracolumbar Spinal Cord Injury.Frontiers in veterinary science · 2020Review
- Predictors of Response to 4-Aminopyridine in Chronic Canine Spinal Cord Injury.Journal of neurotrauma · 2019Article
- Time course and prognostic value of serum GFAP, pNFH, and S100β concentrations in dogs with complete spinal cord injury because of intervertebral disc extrusion.Journal of veterinary internal medicine · 2019Article
- Diffusion Tensor Imaging in Diagnosis of Post-Traumatic Syringomyelia in Spinal Cord Injury in Rats.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Lesion heterogeneity among chronically paralyzed dogs after acute, complete thoracolumbar spinal cord injury (TLSCI) is poorly described. We hypothesized that lesion severity quantified by diffusion tensor imaging (DTI) is associated with hindlimb motor function. Our objectives were to quantify lesion severity with fractional anisotropy (FA), mean diffusivity (MD), and tractography and investigate associations with motor function. Twenty-two dogs with complete TLSCI in the chronic stage were enrolled and compared with six control dogs. All underwent thoracolumbar magnetic resonance imaging (MRI) with DTI and gait analysis. FA and MD were calculated on regions of interest (ROI) at the lesion epicenter and cranial and caudal to the visible lesion on conventional MRI and in corresponding ROI in controls. Tractography was performed to detect translesional fibers. Gait was quantified using an ordinal scale (OFS). FA and MD values were compared between cases and controls, and relationships between FA, MD, presence of translesional fibers and OFS were investigated. The FA at the epicenter (median: 0.228, 0.107-0.320), cranial (median: 0.420, 0.391-0.561), and caudal to the lesion (median: 0.369, 0.265-0.513) was lower than combined ROI in controls (median: 0.602, 0.342-0.826, p < 0.0001). The MD at the epicenter (median: 2.06 × 10
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