Evidence map›Paper›PMID 28974067›Full record

ArticleBritish journal of anaesthesia2017

High intraoperative inspiratory oxygen fraction and risk of major respiratory complications.

A K Staehr-Rye, C S Meyhoff, F T Scheffenbichler, M F Vidal Melo, M R Gätke, J L Walsh, K S Ladha, S D Grabitz, M I Nikolov, T Kurth and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of anaesthesia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02399878 (Intra-operative Inspiratory Oxygen Fraction and Postoperative Respiratory Complications), which is not on this map. Cited by 71 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 5 pooled it
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02399878 unknown statusnot on this map

Intra-operative Inspiratory Oxygen Fraction and Postoperative Respiratory Complications

TypeobservationalSponsorMassachusetts General HospitalRan2007Enrolled70,000ConditionsRespiratory Failure, Acute Respiratory Failure Requiring Intubation, Pulmonary Edema, PneumoniaArmsInspiratory oxygen
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 5 syntheses or guidelines pooled it, 175 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Hypoxemia in trauma patients receiving two different oxygen strategies: a TRAUMOX2 substudy.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025
    Trial
  8. Trial
  9. Effects of intraoperative inspired oxygen fraction (FiOCritical care (London, England) · 2023
    Trial
  10. Trial
  11. Trial
  12. Article
  13. Article
  14. Article
  15. Article
  16. FiOFrontiers in medicine · 2026
    Article
  17. Review
  18. Article
  19. Article
  20. Observational

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

A K Staehr-RyeDepartment of Anaesthesia, Critical Care, Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
C S MeyhoffDepartment of Anaesthesiology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev Ringvej 75, 2730 Herlev, Denmark.
F T ScheffenbichlerDepartment of Anaesthesia, Critical Care, Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
M F Vidal MeloDepartment of Anaesthesia, Critical Care, Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
M R GätkeDepartment of Anaesthesiology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev Ringvej 75, 2730 Herlev, Denmark.
J L WalshDepartment of Anaesthesia, Critical Care, Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
K S LadhaDepartment of Anaesthesia, Critical Care, Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
S D GrabitzDepartment of Anaesthesia, Critical Care, Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
M I NikolovDepartment of Anaesthesia, Critical Care, Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
T KurthInstitute of Public Health, Charité Universitätzmedizin Berlin, Germany.
L S RasmussenDepartment of Anaesthesia, Centre of Head and Orthopaedics, Rigshospitalet, University of Copenhagen, Denmark.
M EikermannDepartment of Anaesthesia, Critical Care, Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Massachusetts General Hospital · USUniversity of Copenhagen · DKCharité - Universitätsmedizin Berlin · DERigshospitalet · DK

Funding

Intraoperative Protective Ventilation and Postoperative Pulmonary ComplicationsR34HL123438 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI VIDAL MELO, MARCOS F · 2015 to 2017
$599k
NHLBI NIH HHS R34 HL123438
6 · The paper itself

Abstract

backgroundHigh inspiratory oxygen fraction ( FIO2 ) may improve tissue oxygenation but also impair pulmonary function. We aimed to assess whether the use of high intraoperative FIO2 increases the risk of major respiratory complications.

methodsWe studied patients undergoing non-cardiothoracic surgery involving mechanical ventilation in this hospital-based registry study. The cases were divided into five groups based on the median FIO2 between intubation and extubation. The primary outcome was a composite of major respiratory complications (re-intubation, respiratory failure, pulmonary oedema, and pneumonia) developed within 7 days after surgery. Secondary outcomes included 30-day mortality. Several predefined covariates were included in a multivariate logistic regression model.

resultsThe primary analysis included 73 922 cases, of whom 3035 (4.1%) developed a major respiratory complication within 7 days of surgery. For patients in the high- and low-oxygen groups, the median FIO2 was 0.79 [range 0.64-1.00] and 0.31 [0.16-0.34], respectively. Multivariate logistic regression analysis revealed that the median FIO2 was associated in a dose-dependent manner with increased risk of respiratory complications (adjusted odds ratio for high vs low FIO2 1.99, 95% confidence interval [1.72-2.31], P -value for trend <0.001). This finding was robust in a series of sensitivity analyses including adjustment for intraoperative oxygenation. High median FIO2 was also associated with 30-day mortality (odds ratio for high vs low FIO2 1.97, 95% confidence interval [1.30-2.99], P -value for trend <0.001).

conclusionsIn this analysis of administrative data on file, high intraoperative FIO2 was associated in a dose-dependent manner with major respiratory complications and with 30-day mortality. The effect remained stable in a sensitivity analysis controlled for oxygenation. CLINICAL

trial registrationNCT02399878.

Indexed as

AdultAgedFemaleHumansIntraoperative PeriodLogistic ModelsMaleMiddle AgedOxygenOxygen Inhalation TherapyPostoperative ComplicationsRespiration DisordersRespiratory InsufficiencyRiskOxygenoxygenpostoperative complicationsrespiratory insufficiencyrespiratory therapy

Identifiers

PMID28974067
PMCPMC13169008
OpenAlexW2660089904

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.