Evidence map›Paper›PMID 28974006›Full record

ArticleMolecules (Basel, Switzerland)2017

Inhibitory Effects of Total Triterpenoid Saponins Isolated from the Seeds of the Tea Plant (Camellia sinensis) on Human Ovarian Cancer Cells.

Ling-Yan Jia, Xue-Jin Wu, Ying Gao, Gary O Rankin, Alexa Pigliacampi, Heather Bucur, Bo Li, You-Ying Tu, Yi Charlie Chen

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  8. Review
  9. Phytochemicals in Gynecological Cancer Prevention.International journal of molecular sciences · 2021
    Review
  10. Review
  11. Standardized Saponin Extract from Baiye No.1 Tea (Molecules (Basel, Switzerland) · 2020
    Article
  12. Herbal nutraceuticals: safe and potent therapeutics to battle tumor hypoxia.Journal of cancer research and clinical oncology · 2020
    Review
  13. Review
  14. Review
  15. Article
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ling-Yan JiaDepartment of Tea Science, Zhejiang University, Hangzhou 310058, China. 11416013@zju.edu.cn.
Xue-Jin WuDepartment of Tea Science, Zhejiang University, Hangzhou 310058, China. wuxuejin@zju.edu.cn.
Ying GaoTea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310008, China. drlib@zju.edu.cn.
Gary O RankinDepartment of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA. pigliacampiam@battlers.ab.edu.
Alexa PigliacampiCollege of Science, Technology and Mathematics, Alderson Broaddus University, Philippi, WV 26416, USA. bucurhm@battlers.ab.edu.
Heather BucurCollege of Science, Technology and Mathematics, Alderson Broaddus University, Philippi, WV 26416, USA. yinggao@tricaas.com.
Bo LiDepartment of Tea Science, Zhejiang University, Hangzhou 310058, China. rankin@marshall.edu.
You-Ying TuDepartment of Tea Science, Zhejiang University, Hangzhou 310058, China. youytu@zju.edu.cn.
Yi Charlie ChenCollege of Science, Technology and Mathematics, Alderson Broaddus University, Philippi, WV 26416, USA. chenyc@ab.edu.
Alderson Broaddus University · USZhejiang University · CNChinese Academy of Agricultural Sciences · CNMarshall University · US

Funding

WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI Travis Salisbury · 2012 to 2026
$61.1M
WVU &MU NEW FACULTY GRANTSP20RR016477 · NCRR · MARSHALL UNIVERSITY · PI RANKIN, GARY O · 2001 to 2011
$35.5M
Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)P20GM104932 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI MAJUMDAR, SOUMYAJIT · 2012 to 2016
$10.0M
COBRE FOR SIGNAL TRANSDUCTION AND CANCER PHASE IIIP30RR032138 · NCRR · WEST VIRGINIA UNIVERSITY · PI GIBSON, LAURA F. · 2011 to 2011
$1.1M
BECTON-DICKINSON FACSARIA FLOW CYTOMETER: SARCOPENIAS10RR020866 · NCRR · WEST VIRGINIA UNIVERSITY · PI CUFF, CHRISTOPHER F · 2006 to 2006
$425k
Special Becton Dickinson Fortessa Flow CytometerS10OD016165 · OD · WEST VIRGINIA UNIVERSITY · PI CUFF, CHRISTOPHER F · 2013 to 2013
$384k
NCRR NIH HHS P20 RR016477NCRR NIH HHS P30 RR032138NCRR NIH HHS S10 RR020866NIGMS NIH HHS P20 GM103434NIGMS NIH HHS P20 GM104932NIH HHS S10 OD016165
6 · The paper itself

Abstract

Ovarian cancer is regarded as one of the most severe malignancies for women in the world. Death rates have remained steady over the past five decades, due to the undeniable inefficiency of the current treatment in preventing its recurrence and death. The development of new effective alternative agents for ovarian cancer treatment is becoming increasingly critical. Tea saponins (TS) are triterpenoidsaponins composed of sapogenins, glycosides, and organic acids, which possess a variety of pharmacological activities, and have shown promise in the anti-cancer field. Through cell CellTiter 96

Indexed as

Antineoplastic AgentsApoptosisCamellia sinensisCell Culture TechniquesCell Line, TumorCell SurvivalFemaleHumansOleanolic AcidOvarian NeoplasmsPlant ExtractsSaponinsSeedsSignal TransductionTeaTriterpenesAntineoplastic AgentsOleanolic AcidPlant ExtractsSaponinsTeaTriterpenesVascular Endothelial Growth Factor AVEGFA protein, humanangiogenesisapoptosisCamellia sinensisovarian cancertriterpenoid saponins

Identifiers

PMID28974006
PMCPMC6151552
OpenAlexW2763660047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.