ArticleProceedings of the National Academy of Sciences of the United States of America2017
Mediator subunit MED25 links the jasmonate receptor to transcriptionally active chromatin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
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95 citing papers in PubMed, 190 citations in OpenAlex.
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- DELLA proteins interact with HAC1 and control plant growth via transcriptional regulation of the growth repressor gene ERF2.The Plant cell · 2026Article
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- A Cross-Climate Comparison of Molecular Phenology in Three Tropical and Temperate Trees.Plant-environment interactions (Hoboken, N.J.) · 2026Article
- Phytochrome B integrates jasmonic acid and warm temperature signaling pathways to regulate cotyledon chloroplast development.Nature communications · 2026Article
- The environmentally responsive plant epigenome: insights from jasmonate signaling.The New phytologist · 2026Review
- Robustness in jasmonate signaling: mechanisms of concerted regulation and implications for crop improvement.aBIOTECH · 2025Review
- EIN3-binding F-box protein SlEBF3 modulates resistance againstHorticulture research · 2025Article
- CsJAZ11 positively regulates tea plant resistance to Colletotrichum camelliae via transient silencing and overexpression.Plant cell reports · 2025Article
- GCN5-related histone acetyltransferase HOOKLESS2 regulates fungal resistance and growth in tomato.The New phytologist · 2025Article
- Histone Modification-Dependent Transcriptional Regulation of Defence Genes in Early Response of Arabidopsis to Spodoptera litura Attack.Plant, cell & environment · 2025Article
- The Role of MYC2 Transcription Factors in Plant Secondary Metabolism and Stress Response Mechanisms.Plants (Basel, Switzerland) · 2025Review
- Natural variation in ZmNRT2.5 modulates husk leaf width and promotes seed protein content in maize.Plant biotechnology journal · 2025Article
- Ethylene increases the NaHCOPlant biotechnology journal · 2025Article
- A semidominant point mutation of Mediator tail subunit MED5b in Arabidopsis leads to altered enrichment of H3K27me3 and reduced expression of targets of MYC2.G3 (Bethesda, Md.) · 2025Article
- A multiprotein regulatory module, MED16-MBR1&2, controls MED25 homeostasis during jasmonate signaling.Nature communications · 2025Article
- High-throughput capture of transcription factor-driven epigenome dynamics using PHILO ChIP-seq.Nucleic acids research · 2024Article
- Loss-of-function of LIGULELESS1 activates the jasmonate pathway and promotes maize resistance to corn leaf aphids.Plant biotechnology journal · 2024Article
- A structure-redesigned intrinsically disordered peptide that selectively inhibits a plant transcription factor in jasmonate signaling.PNAS nexus · 2024Article
- Phytohormones in a universe of regulatory metabolites: lessons from jasmonate.Plant physiology · 2024Review
35 more citing papers are in PubMed but not listed here.
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11 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Jasmonoyl-isoleucine (JA-Ile), the active form of the plant hormone jasmonate (JA), is sensed by the F-box protein CORONATINE INSENSITIVE 1 (COI1), a component of a functional Skp-Cullin-F-box E3 ubiquitin ligase complex. Sensing of JA-Ile by COI1 rapidly triggers genome-wide transcriptional changes that are largely regulated by the basic helix-loop-helix transcription factor MYC2. However, it remains unclear how the JA-Ile receptor protein COI1 relays hormone-specific regulatory signals to the RNA polymerase II general transcriptional machinery. Here, we report that the plant transcriptional coactivator complex Mediator directly links COI1 to the promoters of MYC2 target genes. MED25, a subunit of the Mediator complex, brings COI1 to MYC2 target promoters and facilitates COI1-dependent degradation of jasmonate-ZIM domain (JAZ) transcriptional repressors. MED25 and COI1 influence each other's enrichment on MYC2 target promoters. Furthermore, MED25 physically and functionally interacts with HISTONE ACETYLTRANSFERASE1 (HAC1), which plays an important role in JA signaling by selectively regulating histone (H) 3 lysine (K) 9 (H3K9) acetylation of MYC2 target promoters. Moreover, the enrichment and function of HAC1 on MYC2 target promoters depend on COI1 and MED25. Therefore, the MED25 interface of Mediator links COI1 with HAC1-dependent H3K9 acetylation to activate MYC2-regulated transcription of JA-responsive genes. This study exemplifies how a single Mediator subunit integrates the actions of both genetic and epigenetic regulators into a concerted transcriptional program.
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