Evidence map›Paper›PMID 28973931›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Systems-level identification of PKA-dependent signaling in epithelial cells.

Kiyoshi Isobe, Hyun Jun Jung, Chin-Rang Yang, J'Neka Claxton, Pablo Sandoval, Maurice B Burg, Viswanathan Raghuram, Mark A Knepper

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 137 citations in OpenAlex.

  1. The CTNNB1-TRIM28 complex governs hormone-induced RNA polymerase II dynamics in kidney epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Transcriptional regulatory factors of the Aqp2 gene.Kidney research and clinical practice · 2026
    Article
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  9. Vasopressin-Sensitive Aqp2 Regulation Mediated by the TAZ-NR4A1 Axis in Renal Collecting Duct Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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  18. Proteomics and AQP2 regulation.The Journal of physiology · 2024
    Review
  19. Article
  20. Review

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kiyoshi IsobeEpithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1603.
Hyun Jun JungEpithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1603.
Chin-Rang YangEpithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1603.
J'Neka ClaxtonEpithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1603.
Pablo SandovalEpithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1603.
Maurice B BurgEpithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1603.
Viswanathan RaghuramEpithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1603.
Mark A KnepperEpithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1603 knepperm@nhlbi.nih.gov.
National Institutes of Health · USNational Heart Lung and Blood Institute · US

Funding

Solute And Water Transport In Renal EpitheliaZIAHL001285 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KNEPPER, MARK · 2009 to 2025
$34.9M
Computational Tools for ProteomicsZIAHL006129 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KNEPPER, MARK · 2011 to 2025
$8.1M
Intramural NIH HHS ZIA HL001285Intramural NIH HHS ZIA HL006129
6 · The paper itself

Abstract

G protein stimulatory α-subunit (G

Indexed as

AnimalsAquaporin 2Chromatin ImmunoprecipitationClustered Regularly Interspaced Short Palindromic RepeatsCyclic AMP-Dependent Protein Kinase Catalytic SubunitsE1A-Associated p300 ProteinEpithelial CellsExocytosisGene Knockout TechniquesGTPase-Activating ProteinsKidneyMAP Kinase Kinase Kinase 5MiceMitogen-Activated Protein Kinase 1PhosphorylationProtein Kinase CAqp2 protein, mouseAquaporin 2Cyclic AMP-Dependent Protein Kinase Catalytic SubunitsE1A-Associated p300 ProteinEp300 protein, mouseGTPase-Activating ProteinsMap3k5 protein, mouseMapk1 protein, mouseMAP Kinase Kinase Kinase 5Mitogen-Activated Protein Kinase 1Prkaca protein, mousePrkacb protein, mouseProtein Kinase CRap1GAP protein, mouseVasopressinsCRISPR-Cas9next-generation sequencingphosphoproteomicsprotein mass spectrometryvasopressin

Identifiers

PMID28973931
PMCPMC5651769
OpenAlexW2762504941

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.