ArticleProceedings of the National Academy of Sciences of the United States of America2017
Engineering of tomato for the sustainable production of ketocarotenoids and its evaluation in aquaculture feed.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- Metabolism and regulation of chlorophyll and carotenoids in tomato fruits.Horticulture research · 2026Article
- Metabolically engineered plant cell cultures as biofactories for the production of high-value carotenoids astaxanthin and canthaxanthin.Scientific reports · 2025Article
- EngineeredLife (Basel, Switzerland) · 2025Article
- Effect of Heterologous Expression of Key Enzymes Involved in Astaxanthin and Lipid Synthesis on Lipid and Carotenoid Production inMarine drugs · 2025Article
- Molecular breeding of tomato: Advances and challenges.Journal of integrative plant biology · 2025Review
- Ketocarotenoid production in tomato triggers metabolic reprogramming and cellular adaptation: The quest for homeostasis.Plant biotechnology journal · 2024Article
- Carotenoid Extraction from Plant Tissues.Methods in molecular biology (Clifton, N.J.) · 2024Article
- QTL Mapping of Zeaxanthin Content in Sweet Corn Using Recombinant Inbred Line Population across Different Environments.Plants (Basel, Switzerland) · 2023Article
- The chemotype core collection of genus Nicotiana.The Plant journal : for cell and molecular biology · 2022Article
- Heterologous expression of Bixa orellana cleavage dioxygenase 4-3 drives crocin but not bixin biosynthesis.Plant physiology · 2022Article
- Going red but not mad: efficient astaxanthin production in tobacco without yield penalty.Plant physiology · 2022Article
- Riboswitch-mediated inducible expression of an astaxanthin biosynthetic operon in plastids.Plant physiology · 2022Article
- Engineering high levels of saffron apocarotenoids in tomato.Horticulture research · 2022Article
- Carotenoid Cocktail Produced by An Antarctic SoilMicroorganisms · 2021Article
- Engineering a Plant-Derived Astaxanthin Synthetic Pathway IntoFrontiers in plant science · 2021Article
- Agriculture can help aquaculture become greener.Nature food · 2020Review
- Development of zeaxanthin-rich tomato fruit through genetic manipulations of carotenoid biosynthesis.Plant biotechnology journal · 2020Article
- Canthaxanthin, a Red-Hot Carotenoid: Applications, Synthesis, and Biosynthetic Evolution.Plants (Basel, Switzerland) · 2020Review
- Metabolic engineering of ketocarotenoids biosynthetic pathway in Chlamydomonas reinhardtii strain CC-4102.Scientific reports · 2020Article
- Nutritional enhancement in plants - green and greener.Current opinion in biotechnology · 2020Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Ketocarotenoids are high-value pigments used commercially across multiple industrial sectors as colorants and supplements. Chemical synthesis using petrochemical-derived precursors remains the production method of choice. Aquaculture is an example where ketocarotenoid supplementation of feed is necessary to achieve product viability. The biosynthesis of ketocarotenoids, such as canthaxanthin, phoenicoxanthin, or astaxanthin in plants is rare. In the present study, complex engineering of the carotenoid pathway has been performed to produce high-value ketocarotenoids in tomato fruit (3.0 mg/g dry weight). The strategy adopted involved pathway extension beyond β-carotene through the expression of the β-carotene hydroxylase (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.