Evidence map›Paper›PMID 28973538›Full record

ArticleJAMA ophthalmology2017

Choroidal Features of Acute Macular Neuroretinopathy via Optical Coherence Tomography Angiography and Correlation With Serial Multimodal Imaging.

Sun Young Lee, Justine L Cheng, Karen M Gehrs, James C Folk, Elliott H Sohn, Stephen R Russell, Zhihui Guo, Michael D Abràmoff, Ian C Han

Erratum issuedOpen access · bronzeAbstract readCase Reports
In one paragraph

Article in JAMA ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Acute macular neuroretinopathy: is the name still appropriate?Medical hypothesis, discovery & innovation ophthalmology journal · 2026
    Review
  3. Optical coherence tomography angiography suggests choriocapillaris perfusion deficit as etiology of acute macular neuroretinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Acute macular neuroretinopathy in dengue virus serotype 1.American journal of ophthalmology case reports · 2022
    Article
  10. Article
  11. [Long-term follow-up of a young female patient with bilateral acute macular neuroretinopathy].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2022
    Article
  12. Article
  13. [Flickering scotoma after COVID vaccination : A further possible side effect of vaccination?]Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Acute Macular Neuroretinopathy in Purtscher Retinopathy.Turkish journal of ophthalmology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sun Young LeeDepartment of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City.
Justine L ChengCarver College of Medicine, University of Iowa, Iowa City.
Karen M GehrsDepartment of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City.
James C FolkDepartment of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City.
Elliott H SohnDepartment of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City.
Stephen R RussellDepartment of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City.
Zhihui GuoDepartment of Biomedical Engineering, University of Iowa, Iowa City.
Michael D AbràmoffDepartment of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City.
Ian C HanDepartment of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City.
University of Iowa · US

Funding

Stem Cell and Organoid CoreP30EY025580 · NEI · UNIVERSITY OF IOWA · PI Michael G Anderson, Robert Foster Mullins · 2016 to 2026
$6.9M
NEI NIH HHS P30 EY025580
6 · The paper itself

Abstract

Importance: Acute macular neuroretinopathy (AMN) is a rare, idiopathic condition resembling other acute maculopathies such as paracentral acute middle maculopathy. The pathophysiology of AMN is not well understood, and the role of the choroid in the pathogenesis of AMN remains controversial. Objective: To describe initial and serial multimodal imaging findings in AMN, with attention to choroidal vascular changes. Design, Setting, and Participants: Retrospective case series at a single institution, tertiary referral center. The case series included 7 patients with clinical diagnosis of AMN. Main Outcomes and Measures: Multimodal imaging findings, including fundus photography, fluorescein angiography, spectral-domain optical coherence tomography (OCT), en face near-infrared imaging, fundus autofluorescence, optical coherence tomography angiography (OCTA), and automated quantification of the regional structural context of choroidal flow interest between different imaging modalities, using an automatic algorithm. Results: Nine eyes from 7 patients (5 women and 2 men; mean age, 40.1 years) with a diagnosis of AMN were included. Mean duration of follow-up was 11 weeks (range, 1-25 weeks). All eyes had inner choroidal flow void on OCTA that topographically corresponded to regions of abnormal hyperreflectance of the outer retinal layers on spectral-domain OCT and hyporeflectance on en face near-infrared imaging (dice similarity coefficient, 0.76). For each patient, these areas of choroidal flow void on OCTA persisted during the follow-up period, while the abnormal hyperreflectance of outer plexiform layer and inner nuclear layer on spectral-domain OCT was observed to improve. Conclusions and Relevance: These findings suggest that areas of inner choroidal vascular flow void on OCTA are seen in patients with AMN. These areas may persist weeks after the onset of symptoms and suggest that vascular compromise of the inner choroid may be involved in the pathogenesis of AMN.

Indexed as

Acute DiseaseAdultChoroidFemaleFluorescein AngiographyFollow-Up StudiesFundus OculiHumansMacula LuteaMaleMiddle AgedMultimodal ImagingRetinal DiseasesRetrospective StudiesTime FactorsTomography, Optical Coherence

Identifiers

PMID28973538
PMCPMC5710376
OpenAlexW2758446552

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.