ArticleNucleic acids research2017
Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus.
Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 67 citations in OpenAlex.
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- Medicinal Plants: A Promising Therapeutic Approach for Addressing Antimicrobial Resistance.International journal of molecular sciences · 2026Review
- Conformational analysis of different tautomers of some antibiotics.Journal of molecular modeling · 2026Article
- Utilization of probiotics against virulence factors of Staphylococcus aureus in bovine mastitis.Antonie van Leeuwenhoek · 2025Review
- Review
- Clindamycin: A Comprehensive Status Report with Emphasis on Use in Dermatology.The Journal of clinical and aesthetic dermatology · 2024Review
- Recent development and fighting strategies for lincosamide antibiotic resistance.Clinical microbiology reviews · 2024Review
- Scientific Rationale and Clinical Basis for Clindamycin Use in the Treatment of Dermatologic Disease.Antibiotics (Basel, Switzerland) · 2024Review
- One-pot chemoenzymatic syntheses of non-canonical amino acids.Journal of industrial microbiology & biotechnology · 2024Review
- Structural conservation of antibiotic interaction with ribosomes.Nature structural & molecular biology · 2023Article
- Structural basis for HflXr-mediated antibiotic resistance in Listeria monocytogenes.Nucleic acids research · 2022Article
- Transcriptomic analysis of Staphylococcus equorum KM1031 from the high-salt fermented seafood jeotgal under chloramphenicol, erythromycin and lincomycin stresses.Scientific reports · 2022Article
- Visible-Light-Mediated Stadler-Ziegler Arylation of Thiosugars with Anilines.ACS organic & inorganic Au · 2022Article
- Synthetic oxepanoprolinamide iboxamycin is active againstJAC-antimicrobial resistance · 2022Article
- Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.Nature communications · 2022Article
- Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia.Nucleic acids research · 2022Article
- Machine learning approaches to optimize small-molecule inhibitors for RNA targeting.Journal of cheminformatics · 2022Article
- Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida.Nucleic acids research · 2021Article
- Inhibition of the Eukaryotic 80S Ribosome as a Potential Anticancer Therapy: A Structural Perspective.Cancers · 2021Review
- Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens.Nature communications · 2021Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial resistance within a wide range of pathogenic bacteria is an increasingly serious threat to global public health. Among these pathogenic bacteria are the highly resistant, versatile and possibly aggressive bacteria, Staphylococcus aureus. Lincosamide antibiotics were proved to be effective against this pathogen. This small, albeit important group of antibiotics is mostly active against Gram-positive bacteria, but also used against selected Gram-negative anaerobes and protozoa. S. aureus resistance to lincosamides can be acquired by modifications and/or mutations in the rRNA and rProteins. Here, we present the crystal structures of the large ribosomal subunit of S. aureus in complex with the lincosamides lincomycin and RB02, a novel semisynthetic derivative and discuss the biochemical aspects of the in vitro potency of various lincosamides. These results allow better understanding of the drugs selectivity as well as the importance of the various chemical moieties of the drug for binding and inhibition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.