ArticleInvestigative ophthalmology & visual science2017
Metrics and Acquisition Modes for Fixation Stability as a Visual Function Biomarker.
Article in Investigative ophthalmology & visual science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Fixation Task: A Simple Eye Movement Task Reveals an Impairment in Schizophrenia.Schizophrenia bulletin · 2026Article
- Detection of Visual Fatigue Using Eye Tracking and a Wearable Device.Investigative ophthalmology & visual science · 2026Article
- Structure-Function Correlation Using a Targeted Image-Guided Microperimetry Approach for Retinal Atrophic Diseases: A Methods Study.Translational vision science & technology · 2025Article
- The vertical position of visual information conditions spatial memory performance in healthy aging.Communications psychology · 2023Article
- Eye Tracking in Optometry: A Systematic Review.Journal of eye movement research · 2023Article
- Alterations in Fixation Indices in Primary Open-Angle Glaucoma by Microperimetry.Journal of clinical medicine · 2022Article
- Fundus motion during mfERG testing.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- Clinical Perspectives and Trends: Microperimetry as a Trial Endpoint in Retinal Disease.Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde · 2021Review
- A Workshop on Measuring the Progression of Atrophy Secondary to Stargardt Disease in the ProgStar Studies: Findings and Lessons Learned.Translational vision science & technology · 2019Article
- Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) Study: Design and Baseline Characteristics (Report No. 1).Ophthalmic research · 2019Article
- Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps.Translational vision science & technology · 2018Article
- The role of multimodal imaging and vision function testing inTherapeutic advances in ophthalmologyReview
- Microperimetry for geographic atrophy secondary to age-related macular degeneration.Survey of ophthalmologyReview
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 4 countries.
Funding
Abstract
Purpose: To compare different metrics and acquisition modes of fixation stability as a new visual function biomarker in a large cohort of patients with ABCA4-related Stargardt disease from the multicenter prospective ProgStar study. Methods: Fixation was tested during a separate fixation exam and also dynamically during a sensitivity exam, using fundus-tracking microperimetry (Nidek MP-1). Fixation data were analyzed using the bivariate contour ellipse area (BCEA), the 2/4 degree method, and the Fujii classification. Results: In a total of 235 patients, the mean BCEA was larger when measured during the sensitivity exam (418 eyes; 12.5 vs. 4.6 deg2 during the fixation task in 427 eyes). Correlations between the two tests were generally weak. Fixation stability during the sensitivity test was significantly correlated with visual acuity. Comparing the BCEA values and the corresponding Fujii categories for these eyes revealed ranges of overlap where an eye with one defined BCEA value can fall into each of the three Fujii categories. Conclusions: Patients may have limited ability to fixate over defined time periods, which leads to significant differences between shorter and longer measurements of fixation stability. The most appropriate way to use this functional biomarker appears to be using continuous metrics for fixation stability, such as the BCEA, during a macular sensitivity test.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.