ArticlePloS one2017
The impact of cardiovascular risk factors on cardiac structure and function: Insights from the UK Biobank imaging enhancement study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 70 citations in OpenAlex.
- Circulating PCSK9: A new frontier in cancer risk stratification for obese diabetics.Oncology letters · 2026Article
- Associations of Metabolic Phenotypes with Cardiac Structure and Clinical Outcomes: Insights from the UK Biobank.The Journal of clinical endocrinology and metabolism · 2026Article
- Association of Cardiovascular Health and Genetic Risk for Left Ventricular Mass with Left Ventricular Structure, Function, and Incident Cardiovascular Outcomes.medRxiv : the preprint server for health sciences · 2026Article
- Smart bio-implants for early detection and proactive management of cardiac Behçet's disease.Annals of medicine and surgery (2012) · 2026Article
- Relationship between left ventricular shape and cardiovascular risk factors: comparison between the Multi-Ethnic Study of Atherosclerosis and UK Biobank.Heart (British Cardiac Society) · 2025Article
- Genetic basis of right and left ventricular heart shape.Nature communications · 2024Article
- Relation of Cognitive Reserve Indicator to Heart Disease and Cardiac Structure and Function: A Large Community-Based Longitudinal Study.Journal of the American Heart Association · 2024Article
- A history of cardiovascular magnetic resonance imaging in clinical practice and population science.Frontiers in cardiovascular medicine · 2024Review
- Association between subclinical atherosclerosis and cardiac structure and function-results from the UK Biobank Study.European heart journal. Imaging methods and practice · 2023Article
- Imaging Early Life Cardiovascular Phenotype.Circulation research · 2023Review
- Prediction of incident cardiovascular events using machine learning and CMR radiomics.European radiology · 2023Article
- Three-Dimensional Automated, Machine-Learning-Based Left Heart Chamber Metrics: Associations with Prevalent Vascular Risk Factors and Cardiovascular Diseases.Journal of clinical medicine · 2022Article
- Certainties and Uncertainties of Cardiac Magnetic Resonance Imaging in Athletes.Journal of cardiovascular development and disease · 2022Review
- Improving explainability of deep neural network-based electrocardiogram interpretation using variational auto-encodersEuropean heart journal. Digital health · 2022Article
- Left atrial structure and function are associated with cardiovascular outcomes independent of left ventricular measures: a UK Biobank CMR study.European heart journal. Cardiovascular Imaging · 2022Article
- Impact of cardiovascular risk factors on myocardial work-insights from the STAAB cohort study.Journal of human hypertension · 2022Article
- Interpretation of pre-morbid cardiac 3T MRI findings in overweight and hypertensive young adults.PloS one · 2022Article
- Cardiac Alterations on 3T MRI in Young Adults With Sedentary Lifestyle-Related Risk Factors.Frontiers in cardiovascular medicine · 2022Article
- Testosterone Level Reduction Increases the 10-Year Risk of Cardiovascular Diseases: A Retrospective Cohort Study in a Taiwanese Young Male Population.Frontiers in cardiovascular medicine · 2022Article
- Prevalence of multimorbidity of cardiometabolic conditions and associated risk factors in a population-based sample of South Africans: A cross-sectional study.Public health in practice (Oxford, England) · 2021Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
aimsThe UK Biobank is a large-scale population-based study utilising cardiovascular magnetic resonance (CMR) to generate measurements of atrial and ventricular structure and function. This study aimed to quantify the association between modifiable cardiovascular risk factors and cardiac morphology and function in individuals without known cardiovascular disease.
methodsAge, sex, ethnicity (non-modifiable) and systolic blood pressure, diastolic blood pressure, smoking status, exercise, body mass index (BMI), high cholesterol, diabetes, alcohol intake (modifiable) were considered important cardiovascular risk factors. Multivariable regression models were built to ascertain the association of risk factors on left ventricular (LV), right ventricular (RV), left atrial (LA) and right atrial (RA) CMR parameters.
results4,651 participants were included in the analysis. All modifiable risk factors had significant effects on differing atrial and ventricular parameters. BMI was the modifiable risk factor most consistently associated with subclinical changes to CMR parameters, particularly in relation to higher LV mass (+8.3% per SD [4.3 kg/m2], 95% CI: 7.6 to 8.9%), LV (EDV: +4.8% per SD, 95% CI: 4.2 to 5.4%); ESV: +4.4% per SD, 95% CI: 3.5 to 5.3%), RV (EDV: +5.3% per SD, 95% CI: 4.7 to 5.9%; ESV: +5.4% per SD, 95% CI: 4.5 to 6.4%) and LA maximal (+8.6% per SD, 95% CI: 7.4 to 9.7%) volumes. Increases in SBP were associated with higher LV mass (+6.8% per SD, 95% CI: 5.9 to 7.7%), LV (EDV: +4.5% per SD, 95% CI: 3.6 to 5.4%; ESV: +2.0% per SD, 95% CI: 0.8 to 3.3%) volumes. The presence of diabetes or high cholesterol resulted in smaller volumes and lower ejection fractions.
conclusionsModifiable risk factors are associated with subclinical alterations in structure and function in all four cardiac chambers. BMI and systolic blood pressure are the most important modifiable risk factors affecting CMR parameters known to be linked to adverse outcomes.
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