ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2017
Neuron-Specific Enolase as an Immunohistochemical Marker Is Better Than Its Reputation.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- A Meta-Analysis of Neuron-Specific Enolase Levels in Cerebrospinal Fluid and Serum in Children With Epilepsy.Frontiers in molecular neuroscience · 2020Pooled it
- Transient Association Between Elevated NSE and Reduced fT3 Levels Following Mild Traumatic Brain Injury: A 12-Month Prospective Pilot Study.Journal of clinical medicine · 2026Article
- Human Meningiomas Reveal No Evidence of Neuroendocrine Differentiation.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Article
- Quiet residents of the vaginal epithelium: immunohistochemical study on the distribution and role of human vaginal Merkel cells.BMC women's health · 2026Article
- Exploring the impact of pre-analytical processes on the determination of neuron-specific enolase in serum samples.Practical laboratory medicine · 2025Article
- Review
- Lung Cancer Biomarkers Associated with Increased Peripheral Arterial Stiffness in Middle-aged Chinese Adults.Journal of atherosclerosis and thrombosis · 2025Article
- Combined CA125, NSE, and multiple inflammatory indices for diagnosis of oral squamous cell carcinoma.Frontiers in oncology · 2025Article
- Neoplasia in the dromedary camel: a review (Frontiers in veterinary science · 2025Review
- Neuroprotective Effects of Myricetin on PTZ-Induced Seizures in Mice: Evaluation of Oxidation, Neuroinflammation and Metabolism, and Apoptosis in the Hippocampus.Current issues in molecular biology · 2024Article
- Gallbladder Neuroendocrine Neoplasms in Dogs and Humans.Veterinary sciences · 2024Review
- Review
- Evaluation and clinical significance of serum neurospecific enolase in children with pneumonia: a case-control study.BMC pediatrics · 2024Article
- Neuron-Specific Enolase-What Are We Measuring?International journal of molecular sciences · 2024Review
- Correctly identifying the cells of origin is essential for tailoring treatment and understanding the emergence of cancer stem cells and late metastases.Frontiers in oncology · 2024Review
- Multifaceted modeling of small intestinal neuroendocrine tumors.Endocrine oncology (Bristol, England) · 2024Review
- Renal neuroendocrine tumour with preoperative diagnostic dilemma.BMJ case reports · 2023Article
- Small Cell Lung Carcinoma: Current Diagnosis, Biomarkers, and Treatment Options with Future Perspectives.Biomedicines · 2023Review
- Co-Expression of Adaptor Protein FAM159B with Different Markers for Neuroendocrine Cells: An Immunocytochemical and Immunohistochemical Study.International journal of molecular sciences · 2022Article
- Investigation of the Molecular Profile of Granular Cell Tumours and Schwannomas of the Oral Cavity.Dentistry journal · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diagnosis of neuroendocrine neoplasms (NENs) may be challenging and is based on typical morphological features and positive staining for antibodies of neuroendocrine differentiation. Neuron-specific enolase (NSE) being a cytosolic marker may be useful in this setting. NSE is by many considered nonspecific, due to the finding of this marker in tumors considered not to be of neuroendocrine origin. Our aim was to determine whether this is true and whether NSE is more specific than previously realized. We examined 178 tumors (carcinomas and NENs) from breast, lung, stomach, and kidney using immunohistochemistry with the following markers: chromogranin A, synaptophysin, CD56, secretagogin, and NSE. Expression of NSE was compared with that of the other markers. NSE was expressed in 138 (78%) of all tumors. Of the NSE-expressing tumors, 95 (68%) cases expressed one or more additional neuroendocrine markers. The staining intensity and number of NSE-expressing tumor cells were highest among tumors of neuroendocrine origin and clear cell renal cell carcinomas. A positive association was found between NSE expression and the number of additional neuroendocrine markers expressed in each of the tumors. Practically all tumors positive for an accepted neuroendocrine marker also expressed NSE.
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