Evidence map›Paper›PMID 28972592›Full record

ArticleTranslational psychiatry2017

Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice.

J Waider, S Popp, M D Lange, R Kern, J F Kolter, J Kobler, N C Donner, K R Lowe, J H Malzbender, C J Brazell and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 4 countries.

J WaiderDivision of Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Wuerzburg, Wuerzburg, Germany.
S PoppDivision of Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Wuerzburg, Wuerzburg, Germany.
M D LangeInstitute of Physiology I, Westfaelische Wilhelms-Universität Muenster, Muenster, Germany.
R KernDivision of Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Wuerzburg, Wuerzburg, Germany.
J F KolterDivision of Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Wuerzburg, Wuerzburg, Germany.
J KoblerDivision of Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Wuerzburg, Wuerzburg, Germany.
N C DonnerDepartment of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
K R LoweDepartment of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
J H MalzbenderDepartment of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
C J BrazellDepartment of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
M R ArnoldDepartment of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
B AboagyeDivision of Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Wuerzburg, Wuerzburg, Germany.
A Schmitt-BöhrerCenter of Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany.
C A LowryDepartment of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
H C PapeInstitute of Physiology I, Westfaelische Wilhelms-Universität Muenster, Muenster, Germany.
K P LeschDivision of Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Wuerzburg, Wuerzburg, Germany.
Social Neuroscience Lab · DEUniversity of Colorado Boulder · USUniversity of Münster · DESechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple lines of evidence implicate brain serotonin (5-hydroxytryptamine; 5-HT) system dysfunction in the pathophysiology of stressor-related and anxiety disorders. Here we investigate the influence of constitutively deficient 5-HT synthesis on stressor-related anxiety-like behaviors using Tryptophan hydroxylase 2 (Tph2) mutant mice. Functional assessment of c-Fos after associated foot shock, electrophysiological recordings of GABAergic synaptic transmission, differential expression of the Slc6a4 gene in serotonergic neurons were combined with locomotor and anxiety-like measurements in different contextual settings. Our findings indicate that constitutive Tph2 inactivation and consequential lack of 5-HT synthesis in Tph2 null mutant mice (Tph2

Indexed as

Escape ReactionAgoraphobiaAmygdalaAnimalsAnxietyElectroshockFeargamma-Aminobutyric AcidInhibitory Postsynaptic PotentialsMaleMice, KnockoutPanic DisorderRaphe NucleiSerotoninSerotonin Plasma Membrane Transport ProteinsTryptophan Hydroxylasegamma-Aminobutyric AcidSerotoninSerotonin Plasma Membrane Transport ProteinsSlc6a4 protein, mouseTph2 protein, mouseTryptophan Hydroxylase

Identifiers

PMID28972592
PMCPMC5682603
OpenAlexW2764302607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.