SynthesisMolecular psychiatry2018
Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Molecular psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 4 pooled it
9.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 4 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- The genetics of cannabis lifetime use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Pooled it
- A large-scale genome-wide association study meta-analysis of cannabis use disorder.The lancet. Psychiatry · 2020Pooled it
- Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals.Nature communications · 2020Pooled it
- From genes to treatments: a systematic review of the pharmacogenetics in smoking cessation.Pharmacogenomics · 2018Pooled it
- Review
- Elucidating neuroepigenetic mechanisms to inform targeted therapeutics for brain disorders.iScience · 2025Review
- Species-specific circular RNA circDS-1 enhances adaptive evolution in Talaromyces marneffei through regulation of dimorphic transition.PLoS genetics · 2025Article
- The genetic landscape of substance use disorders.Molecular psychiatry · 2024Review
- Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Partitioning the Genomic Components of Behavioral Disinhibition and Substance Use (Disorder) Using Genomic Structural Equation Modeling.Behavior genetics · 2024Article
- Single nucleotide variants in lung cancer.Chinese medical journal pulmonary and critical care medicine · 2024Review
- Deep sequencing of candidate genes identified 14 variants associated with smoking abstinence in an ethnically diverse sample.Scientific reports · 2024Article
- Article
- Testing Association of Previously Implicated Gene Sets and Gene-Networks in Nicotine Exposed Mouse Models with Human Smoking Phenotypes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Article
- Global burden of cancers attributable to tobacco smoking, 1990-2019: an ecological study.The EPMA journal · 2023Article
- Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders.Nature. Mental health · 2023Article
- Lack of racial and ethnic diversity in lung cancer cell lines contributes to lung cancer health disparities.Frontiers in oncology · 2023Review
- Association of nicotine dependence and gut microbiota: a bidirectional two-sample Mendelian randomization study.Frontiers in immunology · 2023Article
- Genetic insights into smoking behaviours in 10,558 men of African ancestry from continental Africa and the UK.Scientific reports · 2022Article
- SNP rs9387478 at ROS1-DCBLD1 Locus is Significantly Associated with Lung Cancer Risk and Poor Survival in Indian Population.Asian Pacific journal of cancer prevention : APJCP · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors at 19 institutions in 6 countries.
D B HancockBehavioral and Urban Health Program, Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park, NC, USA. dhancock@rti.org.
Y GuoCenter for Genomics in Public Health and Medicine, RTI International, Research Triangle Park, NC, USA.
G W ReginssondeCODE Genetics/Amgen, Reykjavik, Iceland.
N C GaddisResearch Computing Division, RTI International, Research Triangle Park, NC, USA.
S M LutzDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
R ShervaDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
A LoukolaInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
C C MinicaDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
C A MarkunasBehavioral and Urban Health Program, Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park, NC, USA.
Y HanBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
K A YoungDepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
D F GudbjartssondeCODE Genetics/Amgen, Reykjavik, Iceland.
F GuGenetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, USA.
D W McNeilDepartment of Psychology, West Virginia University, Morgantown, WV, USA.
B QaiserInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
C GlasheenBehavioral and Urban Health Program, Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park, NC, USA.
S OlsonPublic Health Informatics Program, eHealth, Quality and Analytics Division, RTI International, Research Triangle Park, NC, USA.
M T LandiGenetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, USA.
P A F MaddenDepartment of Psychiatry, Washington University, St. Louis, MO, USA.
L A FarrerDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
J VinkDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
N L SacconeDepartment of Genetics, Washington University, St. Louis, MO, USA.
M C NealeVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
H R KranzlerDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
J McKayInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
R J HungLunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, ON, Canada.
C I AmosBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
M L MarazitaCenter for Craniofacial and Dental Genetics, Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA, USA.
D I BoomsmaDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
T B BakerCenter for Tobacco Research and Intervention, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
J GelernterDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
J KaprioInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
N E CaporasoGenetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, USA.
T E ThorgeirssondeCODE Genetics/Amgen, Reykjavik, Iceland.
J E HokansonDepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
L J BierutDepartment of Psychiatry, Washington University, St. Louis, MO, USA.
K StefanssondeCODE Genetics/Amgen, Reykjavik, Iceland.
E O JohnsonFellow Program and Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park, NC, USA.
RTI International · USdeCODE Genetics (Iceland) · ISUniversity of Colorado Anschutz Medical Campus · USVrije Universiteit Amsterdam · NLWashington University in St. Louis · USBoston University · USDartmouth College · USInstitute for Molecular Medicine Finland · FINational Cancer Institute · USCentre International de Recherche sur le Cancer · FRPhiladelphia VA Medical Center · USSinai Health System · CAUniversity of Helsinki · FIUniversity of Iceland · ISUniversity of Pittsburgh · USUniversity of Wisconsin–Madison · USVA Connecticut Healthcare System · USVirginia Commonwealth University · USWest Virginia University · US
Funding
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3MGenetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MPsychosocial Influences on Rural Children's Oral HealthR01DE014899 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FOXMAN, BETSY, MARAZITA, MARY L. · 2002 to 2020
$39.9MMetabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1MTranslating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher I. Amos · 2017 to 2026
$23.7MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9MEnhancing the Effectiveness of Varenicline Based Smoking Cessation TreatmentR01HL109031 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BAKER, TIMOTHY B, STEIN, JAMES H · 2011 to 2020
$17.5MThe Collaborative Genetic Study of Nicotine DependenceP01CA089392 · NCI · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2001 to 2012
$17.3MSex-specific analysis of opioid dependence GWAS and beyondR01DA012690 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2000 to 2017
$14.0MGENETICS OF COCAINE DEPENDENCER01DA012849 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 1999 to 2010
$11.5MTransdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9MMedical Research Council MC_QA137853NCI NIH HHS P01 CA089392NCI NIH HHS P30 CA023108NCI NIH HHS U19 CA148127NCI NIH HHS U19 CA203654NHLBI NIH HHS K01 HL125858NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R01 HL109031NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NIAAA NIH HHS R01 AA011330NIAAA NIH HHS R01 AA017535NIDA NIH HHS P50 DA019706NIDA NIH HHS R01 DA012690NIDA NIH HHS R01 DA012849NIDA NIH HHS R01 DA012854NIDA NIH HHS R01 DA017932NIDA NIH HHS R01 DA018432NIDA NIH HHS R01 DA018673NIDA NIH HHS R01 DA025888NIDA NIH HHS R01 DA035825NIDA NIH HHS R01 DA036583NIDA NIH HHS R01 DA042090NIDA NIH HHS RC2 DA028909NIDCR NIH HHS R01 DE014899NIDCR NIH HHS U01 DE018903World Health Organization 001
Abstract
Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly established associations with sequence variants in nicotine acetylcholine receptor genes and at other loci. To search for additional loci, we conducted a genome-wide association study (GWAS) meta-analysis of nicotine dependence, totaling 38,602 smokers (28,677 Europeans/European Americans and 9925 African Americans) across 15 studies. In this largest-ever GWAS meta-analysis for nicotine dependence and the largest-ever cross-ancestry GWAS meta-analysis for any smoking phenotype, we reconfirmed the well-known CHRNA5-CHRNA3-CHRNB4 genes and further yielded a novel association in the DNA methyltransferase gene DNMT3B. The intronic DNMT3B rs910083-C allele (frequency=44-77%) was associated with increased risk of nicotine dependence at P=3.7 × 10
Indexed as
AdultAgedAllelesBlack or African AmericanBlack PeopleDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BFemaleGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3B
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