Evidence map›Paper›PMID 28972551›Full record

ArticleViruses2017

Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference.

Alexandre Sze, David Olagnier, Samar Bel Hadj, Xiaoying Han, Xiao Hong Tian, Hong-Tao Xu, Long Yang, Qingwen Shi, Penghua Wang, Mark A Wainberg and 2 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Discovery of Two GSK3β Inhibitors fromCurrent computer-aided drug design · 2026
    Article
  2. An Overview of Zika Virus and Zika Virus Induced Neuropathies.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Review
  5. Natural products as Zika antivirals.Medicinal research reviews · 2022
    Review
  6. Flavonoids as Molecules With Anti-Frontiers in microbiology · 2021
    Review
  7. Article
  8. International journal of molecular sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Alexandre SzeDepartment of Medicine, Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, QC, H3T 1E2, Canada. alexandre.sze@mail.mcgill.ca.
David OlagnierDepartment of Medicine, Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, QC, H3T 1E2, Canada. olagnier@biomed.au.dk.
Samar Bel HadjDepartment of Medicine, Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, QC, H3T 1E2, Canada. sbelhadj@jgh.mcgill.ca.
Xiaoying HanDepartment of Medicine, Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, QC, H3T 1E2, Canada. xiaoying.han@mail.mcgill.ca.
Xiao Hong TianDepartment of Medicine, Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, QC, H3T 1E2, Canada. tianxiao037@gmail.com.
Hong-Tao XuDepartment of Medicine, Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, QC, H3T 1E2, Canada. hongtaoxu_00@yahoo.com.
Long YangDepartment of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA. langyangrich@hotmail.com.
Qingwen ShiSchool of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, Hebei 050017, China. mark.wainberg@mcgill.ca.
Penghua WangDepartment of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA. penghua_wang@nymc.edu.
Mark A WainbergDepartment of Medicine, Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, QC, H3T 1E2, Canada. Jian.h.wu@mcgill.ca.
Jian Hui WuDepartment of Medicine, Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, QC, H3T 1E2, Canada. shiqingwen@hebmu.edu.cn.
Rongtuan LinDepartment of Medicine, Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, QC, H3T 1E2, Canada. rongtuan.lin@mcgill.ca.ORCID 0000-0002-2238-3503
Jewish General Hospital · CANew York Medical College · USHebei Medical University · CN

Funding

CIHR MOP130401
6 · The paper itself

Abstract

Flaviviruses including Zika, Dengue and Hepatitis C virus cause debilitating diseases in humans, and the former are emerging as global health concerns with no antiviral treatments. We investigated

Indexed as

Antiviral AgentsCell LineDengueDengue VirusDrug DiscoveryFlavanonesFlaviviridaeHepacivirusHumansPlant RootsRNA-Dependent RNA PolymeraseSophoraVirus ReplicationZika VirusZika Virus InfectionAntiviral AgentsFlavanonesRNA-Dependent RNA PolymerasevexibinolantiviralDengue virusflavivirusRNA polymerasetherapyZika virus

Identifiers

PMID28972551
PMCPMC5691638
OpenAlexW2763931854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.