ReviewDevelopmental medicine and child neurology2017
Motor system plasticity after unilateral injury in the developing brain.
Review in Developmental medicine and child neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04250454 (Protocol of a Two-group Open-label Randomized Clinical Trial With Blinded Assessment for Prevention of Contractures in Infants With High Risk of Cerebral Palsy.), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Protocol of a Two-group Open-label Randomized Clinical Trial With Blinded Assessment for Prevention of Contractures in Infants With High Risk of Cerebral Palsy.
Who cites it
20 citing papers in PubMed.
- The role of independent walking in the maturation of the spinal locomotor output in children with cerebral palsy.Frontiers in physiology · 2026Article
- A narrative review of motor control dual pathways: the corticospinal and reticulospinal tracts in synergy and differentiation.Frontiers in neuroanatomy · 2026Review
- Narrative Review of the Theoretical-Methodological Foundations of the TREINI Program.Children (Basel, Switzerland) · 2024Review
- Linking corticospinal tract activation and upper-limb motor control in adults with cerebral palsy.Developmental medicine and child neurology · 2024Article
- Spinal cord H-reflex post-activation depression is linked with hand motor control in adults with cerebral palsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- Structural networking of the developing brain: from maturation to neurosurgical implications.Frontiers in neuroanatomy · 2023Review
- Restoring After Central Nervous System Injuries: Neural Mechanisms and Translational Applications of Motor Recovery.Neuroscience bulletin · 2022Review
- Left-Right Locomotor Coordination in Human Neonates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Autologous cellular therapy for cerebral palsy: a randomized, crossover trial.Brain communications · 2022Article
- Reduced wrist flexor H-reflex excitability is linked with increased wrist proprioceptive error in adults with cerebral palsy.Frontiers in neurology · 2022Article
- Impact of Rehabilitation Intensity on 3-Year Mortality among Children with Moderate to Severe Cerebral Palsy: A Population-Based Cohort Study.International journal of environmental research and public health · 2021Article
- Transcranial magnetic stimulation as a diagnostic and therapeutic tool in cerebral palsy.Postepy psychiatrii neurologii · 2021Review
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- Article
- Early Diagnostics and Early Intervention in Neurodevelopmental Disorders-Age-Dependent Challenges and Opportunities.Journal of clinical medicine · 2021Review
- Frequency distribution in intraoperative stimulation-evoked EMG responses during selective dorsal rhizotomy in children with cerebral palsy-part 1: clinical setting and neurophysiological procedure.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Maturation of the Locomotor Circuitry in Children With Cerebral Palsy.Frontiers in bioengineering and biotechnology · 2020Review
- Neuronal activity and microglial activation support corticospinal tract and proprioceptive afferent sprouting in spinal circuits after a corticospinal system lesion.Experimental neurology · 2019Article
- Animal models of developmental motor disorders: parallels to human motor dysfunction in cerebral palsy.Journal of neurophysiology · 2019Article
- Rodent Models of Developmental Ischemic Stroke for Translational Research: Strengths and Weaknesses.Neural plasticity · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In maturity, motor skills depend on the corticospinal tract (CST) and brainstem pathways that together synapse on interneurons and motoneurons in the spinal cord. Descending signals to spinal neurons that mediate voluntary control can be distinguished from peripheral sensory signals, primarily for feedback control. These motor system circuits depend initially on developmental genetic mechanisms to establish their connections and neural activity- and use-dependent synaptic refinement during the early postnatal period to enable motor skills to develop. In this review we consider four key activity-dependent developmental mechanisms that provide insights into how the motor systems establish the proper connections for skilled movement control and how the same mechanisms also inform the mechanisms of motor impairments and developmental plasticity after corticospinal system injury: (1) synaptic competition between the CSTs from each hemisphere; (2) interactions between the CST and spinal cord neurons; (3) synaptic competition between the CST and proprioceptive sensory fibres; and (4) interactions between the developing corticospinal motor system and the rubrospinal tract. Our findings suggest that the corticospinal motor system effectively 'oversees' development of its subcortical targets through synaptic competition and trophic-like interactions and this has important implications for motor impairments after perinatal cortical stroke. WHAT THIS PAPER ADDS: Neural activity-dependent processes inform the brain and spinal cord response to injury. The corticospinal motor system may 'oversee' development of its downstream subcortical targets through activity, trophic-like interactions, and synaptic competition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.