Evidence map›Paper›PMID 28972178›Full record

ArticleThe Journal of biological chemistry2017

NK3 homeobox 1 (NKX3.1) up-regulates forkhead box O1 expression in hepatocellular carcinoma and thereby suppresses tumor proliferation and invasion.

Jingyi Jiang, Zheng Liu, Chao Ge, Cong Chen, Fangyu Zhao, Hong Li, Taoyang Chen, Ming Yao, Jinjun Li

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Jingyi JiangFrom the Shanghai Medical College, Fudan University, Shanghai 200032.
Zheng LiuFrom the Shanghai Medical College, Fudan University, Shanghai 200032.
Chao Gethe State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, and.
Cong Chenthe State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, and.
Fangyu Zhaothe State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, and.
Hong Lithe State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, and.
Taoyang Chenthe Qi Dong Liver Cancer Institute, Qi Dong 226200, China.
Ming Yaothe State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, and.
Jinjun Lithe State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, and jjli@shsci.org.
State Key Laboratory of Oncogene and Related Genes · CNQidong Liver Cancer Prevention Research · CNRenji Hospital · CNShanghai Cancer Institute · CNShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related mortality in China, and the molecular mechanism of uncontrolled HCC progression remains to be explored. NK3 homeobox 1 (

Indexed as

Cell ProliferationGene Expression Regulation, NeoplasticAnimalsApoptosisBiomarkers, TumorCarcinoma, HepatocellularCase-Control StudiesCell CycleCell MovementForkhead Box Protein O1Homeodomain ProteinsHumansLiver NeoplasmsMaleMiceMice, Inbred NODBiomarkers, TumorForkhead Box Protein O1FOXO1 protein, humanHomeodomain ProteinsNKX3-1 protein, humanTranscription Factorscell proliferationFOXOhepatocellular carcinomametastasisNK3 Homeobox 1tumor suppressor gene

Identifiers

PMID28972178
PMCPMC5702659
OpenAlexW2764057678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.