Evidence map›Paper›PMID 28972165›Full record

ArticleThe Journal of biological chemistry2017

Surfactant protein A down-regulates epidermal growth factor receptor by mechanisms different from those of surfactant protein D.

Yoshihiro Hasegawa, Motoko Takahashi, Shigeru Ariki, Atsushi Saito, Yasuaki Uehara, Rina Takamiya, Koji Kuronuma, Hirofumi Chiba, Yuji Sakuma, Hiroki Takahashi and 1 more

Open access · hybridAbstract readComparative Study
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Dual Effect ofBiology · 2026
    Article
  3. Review
  4. The Immune Modulatory Role of Surfactants inJournal of inflammation research · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Genetic disorders of the surfactant system: focus on adult disease.European respiratory review : an official journal of the European Respiratory Society · 2021
    Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Yoshihiro HasegawaFrom the Departments of Biochemistry, y-hasegawa@sapmed.ac.jp.
Motoko TakahashiFrom the Departments of Biochemistry.
Shigeru ArikiFrom the Departments of Biochemistry.
Atsushi SaitoFrom the Departments of Biochemistry.
Yasuaki UeharaFrom the Departments of Biochemistry.
Rina TakamiyaFrom the Departments of Biochemistry.
Koji KuronumaRespiratory Medicine and Allergology, and.
Hirofumi ChibaRespiratory Medicine and Allergology, and.
Yuji SakumaMolecular Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan.
Hiroki TakahashiRespiratory Medicine and Allergology, and.
Yoshio KurokiFrom the Departments of Biochemistry.
Respiratory Clinical Trials · AUSapporo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recently reported that the lectin surfactant protein D (SP-D) suppresses epidermal growth factor receptor (EGFR) signaling by interfering with ligand binding to EGFR through an interaction between the carbohydrate-recognition domain (CRD) of SP-D and

Indexed as

Signal TransductionA549 CellsAnimalsCell Line, TumorCell MovementCell ProliferationCHO CellsCricetulusEpidermal Growth FactorErbB ReceptorsHumansLigandsPeptide FragmentsPhosphorylationProtein Interaction Domains and MotifsProtein Interaction MappingEGFR protein, humanEpidermal Growth FactorErbB ReceptorsLigandsPeptide FragmentsPulmonary Surfactant-Associated Protein APulmonary Surfactant-Associated Protein DRecombinant Fusion ProteinsRecombinant Proteinscollectinepidermal growth factor receptor (EGFR)lung canceroligomerizationpulmonary surfactant

Identifiers

PMID28972165
PMCPMC5682966
OpenAlexW2760098927

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.