ArticleThe Journal of biological chemistry2017
An N-terminal di-proline motif is essential for fatty acid-dependent degradation of Δ9-desaturase in
Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Stearoyl-CoA desaturase 5 (SCD5) in lipid remodeling: From molecular control to pathophysiology.Journal of lipid research · 2026Review
- Glutaminase inhibition is correlated with an increase in phospholipid unsaturation, a potential cellular adaptation to pH fluctuations.Scientific reports · 2026Article
- Lactose-Derived Carbohydrates Induce Sexually Dimorphic Nutritional Programming Effects on Lifespan in Drosophila melanogaster.Aging cell · 2026Article
- Desaturase-dependent secretory functions of hepatocyte-like cells control systemic lipid metabolism during starvation in Drosophila.Nature communications · 2025Article
- Allele-specific effect of various dietary fatty acids and ETS1 transcription factor on SCD1 expression.Scientific reports · 2024Article
- Lipid-Mediated Mechanisms of Thermal Adaptation and Thermoregulatory Behavior in Animals.Advances in experimental medicine and biology · 2024Review
- Molecular Basis of Unequal Alternative Splicing of Human SCD5 and Its Alteration by Natural Genetic Variations.International journal of molecular sciences · 2023Article
- Article
- Molecular Mechanisms Underlying the Elevated Expression of a Potentially Type 2 Diabetes Mellitus Associated SCD1 Variant.International journal of molecular sciences · 2022Article
- Understanding and exploiting the fatty acid desaturation system in Rhodotorula toruloides.Biotechnology for biofuels · 2021Article
- Functional expression of Δ12 fatty acid desaturase modulates thermoregulatory behaviour in Drosophila.Scientific reports · 2020Article
- Different mechanisms for selective transport of fatty acids using a single class of lipoprotein inJournal of lipid research · 2019Article
- Organelle aging: Lessons from model organisms.Journal of genetics and genomics = Yi chuan xue bao · 2019Review
- miR‑127 aggravates myocardial failure by promoting the TGF‑β1/Smad3 signaling.Molecular medicine reports · 2018Article
- Co-conspirators in a new mechanism for the degradation of Δ9-desaturase.The Journal of biological chemistry · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Δ9-fatty acid desaturase introduces a double bond at the Δ9 position of the acyl moiety of acyl-CoA and regulates the cellular levels of unsaturated fatty acids. However, it is unclear how Δ9-desaturase expression is regulated in response to changes in the levels of fatty acid desaturation. In this study, we found that the degradation of DESAT1, the sole Δ9-desaturase in the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.