Evidence map›Paper›PMID 28972158›Full record

ArticleThe Journal of biological chemistry2017

Ligand-dependent corepressor (LCoR) represses the transcription factor C/EBPβ during early adipocyte differentiation.

Hongchao Cao, Shengjie Zhang, Shifang Shan, Chao Sun, Yan Li, Hui Wang, Shuxian Yu, Yi Liu, Feifan Guo, Qiwei Zhai and 6 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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  8. Long non-coding RNA H19 in atherosclerosis: what role?Molecular medicine (Cambridge, Mass.) · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Hongchao CaoFrom the Key Laboratories of Food Safety Research and.
Shengjie ZhangFrom the Key Laboratories of Food Safety Research and.
Shifang ShanNutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Chao SunFrom the Key Laboratories of Food Safety Research and.
Yan LiFrom the Key Laboratories of Food Safety Research and.
Hui WangFrom the Key Laboratories of Food Safety Research and.
Shuxian YuFrom the Key Laboratories of Food Safety Research and.
Yi LiuNutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Feifan GuoNutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Qiwei ZhaiNutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Yu-Cheng WangShanghai Xuhui Central Hospital, Shanghai Clinical Center, Chinese Academy of Sciences, Shanghai 200031, China.
Jingjing JiangDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200031, China.
Hui WangFrom the Key Laboratories of Food Safety Research and.
Jun YanModel Animal Research Center, and Ministry of Eduction Key Laboratory of Model Animals for Disease Study, Nanjing University, Nanjing 210061, China.
Wei LiuFrom the Key Laboratories of Food Safety Research and liuwei01@sibs.ac.cn.
Hao YingFrom the Key Laboratories of Food Safety Research and yinghao@sibs.ac.cn.
Shanghai Institutes for Biological Sciences · CNShanghai Xuhui Central Hospital · CNDeleted InstitutionNanjing University · CNThe First Affiliated Hospital, Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nuclear receptors (NRs) regulate gene transcription by recruiting coregulators, involved in chromatin remodeling and assembly of the basal transcription machinery. The NR-associated protein ligand-dependent corepressor (LCoR) has previously been shown to suppress hepatic lipogenesis by decreasing the binding of steroid receptor coactivators to thyroid hormone receptor. However, the role of LCoR in adipogenesis has not been established. Here, we show that LCoR expression is reduced in the early stage of adipogenesis

Indexed as

AdipogenesisGene Expression Regulation3T3-L1 CellsAdipocytesAnimalsCCAAT-Enhancer-Binding Protein-betaGene Knockdown TechniquesMiceProtein Interaction MapsTranscriptional ActivationTranscription FactorsCCAAT-Enhancer-Binding Protein-betaMlr2 protein, mouseTranscription FactorsadipogenesisCCAAT-enhancer-binding protein (C/EBP)nuclear receptorperoxisome proliferator-activated receptor (PPAR)transcription corepressor

Identifiers

PMID28972158
PMCPMC5704479
OpenAlexW2758507870

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.