ArticleThe Journal of biological chemistry2017
Mutant cycle analysis identifies a ligand interaction site in an odorant receptor of the malaria vector
Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Molecular bases of insect odorant receptor function: specificity and evolution.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Template-based modeling of insect odorant receptors outperforms AlphaFold3 for ligand binding predictions.Scientific reports · 2024Article
- The Art and Science of Molecular Docking.Annual review of biochemistry · 2024Review
- A tale of two copies: Evolutionary trajectories of moth pheromone receptors.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Protocol to identify ligands of odorant receptors using two-electrode voltage clamp combined with theSTAR protocols · 2022Article
- Article
- A single point mutation causes one-way alteration of pheromone receptor function in twoiScience · 2021Article
- The whole body transcriptome ofPeerJ · 2020Article
- Pheromone Binding Protein EhipPBP1 Is Highly Enriched in the Male Antennae of the Seabuckthorn Carpenterworm and Is Binding to Sex Pheromone Components.Frontiers in physiology · 2018Article
- Odorant Receptors and Odorant-Binding Proteins as Insect Pest Control Targets: A Comparative Analysis.Frontiers in physiology · 2018Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Lack of information about the structure of insect odorant receptors (ORs) hinders the development of more effective repellants to control disease-transmitting insects. Mutagenesis and functional analyses using agonists to map the odorant-binding sites of these receptors have been limited because mutations distant from an agonist-binding site can alter agonist sensitivity. Here we use mutant cycle analysis, an approach for exploring the energetics of protein-protein or protein-ligand interactions, with inhibitors, to identify a component of the odorant-binding site of an OR from the malaria vector,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.