Evidence map›Paper›PMID 28972127›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Functional Characterization of 5-HT

Hanne D Hansen, Joseph B Mandeville, Christin Y Sander, Jacob M Hooker, Ciprian Catana, Bruce R Rosen, Gitte M Knudsen

Open access · hybridAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Robust changes in brain function require high DNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Review
  3. Article
  4. Advances in simultaneous PET/MR for imaging neuroreceptor function.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Review
  5. Review
  6. In vivo biased agonism at 5-HTNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hanne D HansenNeurobiology Research Unit and NeuroPharm, Copenhagen University Hospital (Rigshospitalet), 2100 Copenhagen, Denmark, hanne.d.hansen@nru.dk.ORCID 0000-0001-5564-7627
Joseph B MandevilleMGH/HST A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and.
Christin Y SanderMGH/HST A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and.
Jacob M HookerMGH/HST A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and.
Ciprian CatanaMGH/HST A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and.
Bruce R RosenMGH/HST A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and.
Gitte M KnudsenNeurobiology Research Unit and NeuroPharm, Copenhagen University Hospital (Rigshospitalet), 2100 Copenhagen, Denmark.ORCID 0000-0003-1508-6866
Massachusetts General Hospital · USCopenhagen University Hospital · DKUniversity of Copenhagen · DK

Funding

Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Advanced Multimodal Neuroimaging Training GrantR90DA023427 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2006 to 2015
$2.8M
MR-assisted PET data optimization for neuroimaging studiesR01EB014894 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI CATANA, CIPRIAN · 2013 to 2016
$2.6M
Combined MRI/PET Imager for Simultaneous Acquisition of PET/MRI DataS10RR022976 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI JENKINS, BRUCE · 2007 to 2007
$2.0M
CYCLOTRON &RADIOCHEMISTRY: SUBSTANCE ABUSE, COCAINE, OPIOIDS10RR017208 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2004 to 2004
$500k
PET CAMERA FOR BRAIN IMAGING: SCHIZOPHRENIA, BIPOLAR DISORDERS10RR019933 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2006 to 2006
$500k
Carbon-11 Radiopharmaceutical Production SystemS10RR026666 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWNELL, ANNA-LIISA · 2010 to 2010
$462k
Imaging dopamine receptor adaptations and signaling pathways with combined PET/fMRIK99DA043629 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI SANDER, CHRISTIN Y. · 2017 to 2018
$372k
NCRR NIH HHS S10 RR017208NCRR NIH HHS S10 RR019933NCRR NIH HHS S10 RR022976NCRR NIH HHS S10 RR026666NIBIB NIH HHS P41 EB015896NIBIB NIH HHS R01 EB014894NIDA NIH HHS K99 DA043629NIDA NIH HHS R90 DA023427
6 · The paper itself

Abstract

In the present study, we used a simultaneous PET-MR experimental design to investigate the effects of functionally different compounds (agonist, partial agonist, and antagonist) on 5-HT

Indexed as

Drug Partial AgonismAnimalsBrainDose-Response Relationship, DrugMacaca mulattaMagnetic Resonance ImagingMalePositron-Emission TomographyReceptor, Serotonin, 5-HT1BSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor AntagonistsReceptor, Serotonin, 5-HT1BSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor Antagonists5-HT1Bnonhuman primatesPET-MR imagingpharmacology

Identifiers

PMID28972127
PMCPMC5666586
OpenAlexW2762061855

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.