Evidence map›Paper›PMID 28972045›Full record

Trial reportClinical cancer research : an official journal of the American Association for Cancer Research2017

Pharmacogenetic Analysis of the UK MRC (Medical Research Council) MAGIC Trial: Association of Polymorphisms with Toxicity and Survival in Patients Treated with Perioperative Epirubicin, Cisplatin, and 5-fluorouracil (ECF) Chemotherapy.

Elizabeth Smyth, Shenli Zhang, David Cunningham, Andrew Wotherspoon, Richie Soong, Clare Peckitt, Nicola Valeri, Matteo Fassan, Massimo Rugge, Alicia Okines and 5 more

Open access · bronzeAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. The density of tumour infiltrating lymphocytes in oesophago-gastric cancer varies with disease stage, geographical region and treatment: a post hoc analysis of nine phase III clinical trials.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Elizabeth SmythDepartment of Gastrointestinal Oncology and Lymphoma, Royal Marsden Hospital, London & Sutton, United Kingdom.
Shenli ZhangCancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.
David CunninghamDepartment of Gastrointestinal Oncology and Lymphoma, Royal Marsden Hospital, London & Sutton, United Kingdom. david.cunningham@rmh.nhs.uk.
Andrew WotherspoonDepartment of Pathology, Royal Marsden Hospital, London & Sutton, United Kingdom.
Richie SoongCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Clare PeckittDepartment of Clinical Research and Development, Royal Marsden Hospital, London & Sutton, United Kingdom.
Nicola ValeriDepartment of Gastrointestinal Oncology and Lymphoma, Royal Marsden Hospital, London & Sutton, United Kingdom.
Matteo FassanDepartment of Medicine, Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy.
Massimo RuggeDepartment of Medicine, Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy.
Alicia OkinesDepartment of Gastrointestinal Oncology and Lymphoma, Royal Marsden Hospital, London & Sutton, United Kingdom.
William AllumDepartment of Medicine, Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy.
Sally StenningDepartment of Surgery, Royal Marsden Hospital, London & Sutton, United Kingdom.
Matthew NankivellDepartment of Surgery, Royal Marsden Hospital, London & Sutton, United Kingdom.
Ruth LangleyMedical Research Council Clinical Trials Unit at UCL, London, United Kingdom.
Patrick TanCancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.
National University Cancer Institute, Singapore · SG

Funding

Cancer Research UK 18052Medical Research Council MC_U122861327Medical Research Council MC_UU_12023/28
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedCisplatinDisease-Free SurvivalDrug-Related Side Effects and Adverse ReactionsEpirubicinEsophageal NeoplasmsFemaleFluorouracilGenetic Association StudiesGenotypeGerm-Line MutationHumansMaleMiddle AgedNeoplasm ProteinsCisplatinEpirubicinFluorouracilNeoplasm ProteinsThymidylate SynthaseTYMS protein, human

Identifiers

PMID28972045
PMCPMC6175041
OpenAlexW2761507559

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.