ArticleAmerican journal of physiology. Renal physiology2018
Early life stress induces immune priming in kidneys of adult male rats.
Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Maternal Separation and Negative Renal Programming, Evidence of Morphofunctional Alterations in Rodent Models: Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Early-Life Stress Programs a Vulnerable Renal Phenotype Under Metabolic Challenge in a Murine Model.Biomolecules · 2026Article
- Early life stress blunts time-of-day-specific autonomic function in adult male mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Contemplative Practices as a Form of Stress Management for Patients with Kidney Disease.Clinical journal of the American Society of Nephrology : CJASN · 2025Review
- Early Postnatal Stress as a Risk Factor for Cardiac Pathology in Systemic Inflammatory Conditions: An Experimental Study.Bulletin of experimental biology and medicine · 2025Article
- Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries.Physiological reviews · 2024Review
- Early life adversity drives sex-specific anhedonia and meningeal immune gene expression through mast cell activation.Brain, behavior, and immunity · 2022Article
- Acclimation to a High-Salt Diet Is Sex Dependent.Journal of the American Heart Association · 2022Article
- Involvement of the Renin-Angiotensin System in Stress: State of the Art and Research Perspectives.Current neuropharmacology · 2022Review
- A Scoping Review of Life-Course Psychosocial Stress and Kidney Function.Children (Basel, Switzerland) · 2021Article
- Adverse childhood events and cardiovascular diseases: the potential role of Sirt1.American journal of physiology. Heart and circulatory physiology · 2021Article
- Early life stress induces dysregulation of the heme pathway in adult mice.Physiological reports · 2021Article
- Traumatic Injury to the Developing Brain: Emerging Relationship to Early Life Stress.Frontiers in neurology · 2021Review
- Maternal separation-induced increases in vascular stiffness are independent of circulating angiotensinogen levels.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Diurnal Control of Blood Pressure Is Uncoupled From Sodium Excretion.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Intrarenal Renin Angiotensin System Imbalance During Postnatal Life Is Associated With Increased Microvascular Density in the Mature Kidney.Frontiers in physiology · 2020Article
- Female Mice Exposed to Postnatal Neglect Display Angiotensin II-Dependent Obesity-Induced Hypertension.Journal of the American Heart Association · 2019Article
- Childhood adversity and mechanistic links to hypertension risk in adulthood.British journal of pharmacology · 2019Review
- Early-life stress and inflammation: A systematic review of a key experimental approach in rodents.Brain and neuroscience advancesReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Early life stress (ELS) in humans is associated with elevated proinflammatory markers. We hypothesized that ELS induces activation of the immune response in a rat model of ELS, maternal separation (MatSep), in adulthood. MatSep involves separating pups from the dam from postnatal day 2 to postnatal day 14 for 3 h/day. Control rats are nonseparated littermates. We determined circulating and renal immune cell numbers, renal immune cell activation markers, renal cytokine levels, and the renal inflammatory gene expression response to low-dose lipopolysaccharide (LPS) in male MatSep and control rats. We observed that MatSep did not change the percentage of gated events for circulating CD3
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.