ArticleHaematologica2017
Molecular and clinical profile of von Willebrand disease in Spain (PCM-EVW-ES): comprehensive genetic analysis by next-generation sequencing of 480 patients.
Registry-linked trialOpen access · goldAbstract readMulticenter Study
In one paragraph
Article in Haematologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02869074 (Molecular and Clinical Profile of Von Willebrand Disease), which is not on this map. Cited by 31 papers.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Molecular and Clinical Profile of Von Willebrand Disease (VWD) in Spain (PCM-EVW-ES). Recruitment Extension, Further Data Analysis, Improvement of Registry Platform, Diagnosis and Management of VWD Application Development
Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- Concomitant acquired and inherited von Willebrand disease: A challenging bleeding disorder.Transfusion · 2026Article
- Landscape and Spectrum of VWF Variants in Type 2 Von Willebrand Disease: Insights from a German Patient Cohort.Thrombosis and haemostasis · 2026Article
- Genetic determinants of clinical variability in type 2 von Willebrand disease: bridging genotype and phenotype.Haematologica · 2026Article
- Prophylaxis for von Willebrand disease: Is it time for parity with established practice in hemophilia A?Therapeutic advances in hematology · 2026Review
- Clinical and laboratory diagnosis of von Willebrand disease.Haematologica · 2026Review
- Molecular genetic testing in von Willebrand disease: past, present, and beyond.Haematologica · 2026Review
- Deep molecular modeling and mechanistic insights into type 2A von Willebrand disease with von Willebrand factor A2 domain mutations.Research and practice in thrombosis and haemostasis · 2025Article
- Integrating Next-Generation Sequencing Into Routine Molecular Diagnosis of Inherited Coagulation Factor Deficiencies: Real-World Data From Spanish Patients.Haemophilia : the official journal of the World Federation of Hemophilia · 2025Article
- Genetic analysis using long-read sequencing to overcome the difficulties inResearch and practice in thrombosis and haemostasis · 2025Article
- Clinical, Phenotypic and Genotypic Characteristics of Von Willebrand Disease in Afro-Caribbeans: Results From a Study in Martinique Island, French West Indies.Haemophilia : the official journal of the World Federation of Hemophilia · 2025Article
- Clinical utility of panel-based genetic sequencing for von Willebrand disease.Research and practice in thrombosis and haemostasis · 2025Article
- Challenges and considerations of genetic testing in von Willebrand disease.Research and practice in thrombosis and haemostasis · 2025Review
- Application of genetic testing for the diagnosis of von Willebrand disease.Journal of thrombosis and haemostasis : JTH · 2024Review
- von Willebrand disease.Nature reviews. Disease primers · 2024Review
- Type 2M/2A von Willebrand disease: a shared phenotype between type 2M and 2A.Blood advances · 2024Article
- The common VWF variant p.Y1584C: detailed pathogenic examination of an enigmatic sequence change.Journal of thrombosis and haemostasis : JTH · 2024Article
- A comparative study in patients with type 2 von Willebrand disease using 4 different platelet-dependent von Willebrand factor assays.Research and practice in thrombosis and haemostasis · 2023Article
- Desmopressin response depends on the presence and type of genetic variants in patients with type 1 and type 2 von Willebrand disease.Blood advances · 2022Article
- Protein S gene mutation c.946C > T (p.R316C) contributed to ischemic stroke in a man with von Willebrand disease type 3 caused by two novel VWF gene mutations, c.2328delT (p.A778Lfs* 23) and c.6521G > T (p.C2174F).Clinical case reports · 2022Article
- Phenotypic and genetic characterizations of the Milan cohort of von Willebrand disease type 2.Blood advances · 2022Article
Corrections and comments
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Authors and funding
49 authors at 20 institutions in 1 country.
Nina BorràsBanc de Sang i Teixits, Barcelona, Spain.
Javier BatlleComplexo Hospitalario Universitario A Coruña, INIBIC, Spain.
Almudena Pérez-RodríguezComplexo Hospitalario Universitario A Coruña, INIBIC, Spain.
María Fernanda López-FernándezComplexo Hospitalario Universitario A Coruña, INIBIC, Spain.
Ángela Rodríguez-TrilloComplexo Hospitalario Universitario A Coruña, INIBIC, Spain.
Esther LourésComplexo Hospitalario Universitario A Coruña, INIBIC, Spain.
Ana Rosa CidHospital Universitario y Politécnico La Fe, Valencia, Spain.
Santiago BonanadHospital Universitario y Politécnico La Fe, Valencia, Spain.
Noelia CabreraHospital Universitario y Politécnico La Fe, Valencia, Spain.
Andrés MoretHospital Universitario y Politécnico La Fe, Valencia, Spain.
Rafael ParraBanc de Sang i Teixits, Barcelona, Spain.
María Eva Mingot-CastellanoHospital Regional Universitario de Málaga, Spain.
Ignacia BaldaHospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain.
Carme AltisentHospital Universitari Vall d'Hebron, Barcelona, Spain.
Rocío Pérez-MontesHospital Universitario Marqués de Valdecilla, Santander, Spain.
Rosa María FisacSalud Castilla y León, Segovia, Spain.
Gemma IruínHospital Universitario Cruces, Barakaldo, Spain.
Sonia HerreroHospital Universitario de Guadalajara, Spain.
Inmaculada SotoHospital Universitario Central de Asturias, Oviedo, Spain.
Beatriz de RuedaHospital Universitario Miguel Servet, Zaragoza, Spain.
Víctor Jiménez-YusteHospital Universitario La Paz, Madrid, Spain.
Nieves AlonsoHospital Infanta Cristina, Badajoz, Spain.
Dolores VilariñoComplejo Hospitalario Universitario Santiago de Compostela, Spain.
Olga ArijaHospital Universitario Lucus Augusti, Lugo, Spain.
Rosa CamposHospital Jerez de la Frontera, Cádiz, Spain.
María José PalomaHospital Virgen del Camino, Pamplona, Spain.
Nuria BermejoHospital San Pedro de Alcántara, Cáceres, Spain.
Rubén BerruecoHospital Sant Joan de Deu, Barcelona, Spain.
José MateoHospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Karmele ArribalzagaHospital Universitario Fundación de Alcorcón, Madrid, Spain.
Pascual MarcoHospital General de Alicante, Spain.
Ángeles PalomoHospital Regional Universitario de Málaga, Spain.
Lizheidy SarmientoHospital Universitario 12 de Octubre, Madrid, Spain.
Belén IñigoHospital Clínico San Carlos, Madrid, Spain.
María Del Mar NietoComplejo Hospitalario de Jaén, Spain.
Rosa VidalFundación Jiménez Díaz, Madrid, Spain.
María Paz MartínezHospital Nuestra Señora de Sonsoles, Ávila, Spain.
Reyes AguinacoHospital Universitario de Tarragona Joan XXIII, Spain.
Jesús María CésarHospital Ramón y Cajal, Madrid, Spain.
María FerreiroHospital Montecelo, Pontevedra, Spain.
Javier García-FradeHospital del Río Hortega, Valladolid, Spain.
Ana María Rodríguez-HuertaHospital Gregorio Marañón, Madrid, Spain.
Jorge CuestaHospital Virgen de la Salud, Toledo, Spain.
Ramón Rodríguez-GonzálezHospital Severo Ochoa, Madrid, Spain.
Faustino García-CandelHospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
Rosa CornudellaHospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.
Carlos AguilarHospital Santa Bárbara, Soria, Spain.
Francisco VidalBanc de Sang i Teixits, Barcelona, Spain icorrales@bst.cat fvidal@bst.cat.
Irene CorralesBanc de Sang i Teixits, Barcelona, Spain icorrales@bst.cat fvidal@bst.cat.
Hospital Universitari i Politècnic La Fe · ESInstituto de Investigación Biomédica de A Coruña · ESBanc de Sang i Teixits · ESComplexo Hospitalario Universitario A Coruña · ESHospital Regional Universitario de Málaga · ESVall d'Hebron Hospital Universitari · ESComplejo Hospitalario de Jaén · ESComplejo Hospitalario Universitario de Santiago · ESHospital Clínico San Carlos · ESHospital Clínico Universitario Lozano Blesa · ESHospital de Cruces · ESHospital de Sant Pau · ESHospital General Universitario de Alicante Doctor Balmis · ESHospital General Universitario Gregorio Marañón · ESHospital Jerez Puerta del Sur · ESHospital Montecelo · ESHospital Nuestra Señora de Alarcos · ESHospital San Pedro de Alcántara · ESHospital Sant Joan de Déu Barcelona · ESHospital Universitari Joan XXIII de Tarragona · ES
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular diagnosis of patients with von Willebrand disease is pending in most populations due to the complexity and high cost of conventional molecular analyses. The need for molecular and clinical characterization of von Willebrand disease in Spain prompted the creation of a multicenter project (PCM-EVW-ES) that resulted in the largest prospective cohort study of patients with all types of von Willebrand disease. Molecular analysis of relevant regions of the
Indexed as
Genetic Association StudiesHigh-Throughput Nucleotide SequencingHumansMutationSpainvon Willebrand Diseasesvon Willebrand Factorvon Willebrand Factor
Identifiers
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LicenceCC BY-NC
Read underepoch 390
Registered trials
NCT02869074ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.