ArticleAntimicrobial agents and chemotherapy2017
Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.
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In one paragraph
Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- d-Cycloserine Pharmacokinetics/Pharmacodynamics, Susceptibility, and Dosing Implications in Multidrug-resistant Tuberculosis: A Faustian Deal.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Pooled it
- Rapid drug resistance prediction in positiveEmerging microbes & infections · 2026Article
- Key Proteins and Enzymatic Mechanisms Underlying Drug Resistance in Mycobacterium tuberculosis.Advances in experimental medicine and biology · 2026Review
- Cycloserine resistance among drug-resistant tuberculosis cases in Taiwan.Microbiology spectrum · 2025Article
- Dual transcriptional inhibition of glutamate and alanine racemase is synergistic inMicrobiology (Reading, England) · 2024Article
- Protocol for the selection ofMethodsX · 2024Article
- Heterologous production of the D-cycloserine intermediate O-acetyl-L-serine in a human type II pulmonary cell model.Scientific reports · 2023Article
- Application of Computational Methods in Understanding Mutations inFrontiers in molecular biosciences · 2021Review
- Antibiotics and resistance: the two-sided coin of the mycobacterial cell wall.Cell surface (Amsterdam, Netherlands) · 2020Review
- c-di-AMP Accumulation Impairs Muropeptide Synthesis in Listeria monocytogenes.Journal of bacteriology · 2020Article
- Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex.Genome medicine · 2020Article
- Comparison of Antibiotic Resistance Mechanisms in Antibiotic-Producing and Pathogenic Bacteria.Molecules (Basel, Switzerland) · 2019Review
- Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes.Nature communications · 2019Article
- Purification, Characterization and Inhibition of Alanine Racemase from a Pathogenic Strain ofPolish journal of microbiology · 2019Article
- Revisiting Anti-tuberculosis Therapeutic Strategies That Target the Peptidoglycan Structure and Synthesis.Frontiers in microbiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 15 institutions in 8 countries.
Yoshio NakataniDepartment of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.
Helen K Opel-ReadingDepartment of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.
Matthias MerkerMolecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
Diana MachadoUnidade de Microbiologia Médica, Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal.
Sönke AndresDivision of Mycobacteriology (National Tuberculosis Reference Laboratory), Research Center Borstel, Borstel, Germany.
S Siva KumarNational Institute for Research in Tuberculosis, Chennai, India.
Danesh MoradigaravandWellcome Trust Sanger Institute, Hinxton, United Kingdom.
Francesc CollLondon School of Hygiene and Tropical Medicine, London, United Kingdom.
João PerdigãoMed.ULisboa-Instituto de Investigação do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal.
Isabel PortugalMed.ULisboa-Instituto de Investigação do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal.
Thomas SchönDepartment of Clinical and Experimental Medicine, Division of Medical Microbiology, Linköping University, Linköping, Sweden.
Dina NairNational Institute for Research in Tuberculosis, Chennai, India.
K R Uma DeviNational Institute for Research in Tuberculosis, Chennai, India.
Thomas A KohlMolecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
Patrick BeckertMolecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
Taane G ClarkLondon School of Hygiene and Tropical Medicine, London, United Kingdom.ORCID 0000-0001-8985-9265
Gugu MaphalalaNational Reference Laboratory, Ministry of Health, Mbabane, Swaziland.
Derrick KhumaloNational Tuberculosis Control Program, Ministry of Health, Manzini, Swaziland.
Roland DielInstitute of Epidemiology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Kadri KlaosTartu University Hospital, United Laboratories, Mycobacteriology, Tartu, Estonia.
Htin Lin AungDepartment of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.ORCID 0000-0002-0465-6256
Gregory M CookDepartment of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.
Julian ParkhillWellcome Trust Sanger Institute, Hinxton, United Kingdom.ORCID 0000-0002-7069-5958
Sharon J PeacockWellcome Trust Sanger Institute, Hinxton, United Kingdom.
Soumya SwaminathanDepartment of Health Research and Director General, Indian Council of Medical Research, New Delhi, India.
Miguel ViveirosUnidade de Microbiologia Médica, Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal.
Stefan NiemannMolecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
Kurt L KrauseMaurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand kurt.krause@otago.ac.nz cuk21@cam.ac.uk.
Claudio U KöserDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom kurt.krause@otago.ac.nz cuk21@cam.ac.uk.ORCID 0000-0002-0232-846X
University of Auckland · NZGerman Center for Infection Research · DENational Institute of Research in Tuberculosis · INLondon School of Hygiene & Tropical Medicine · GBResearch Center Borstel - Leibniz Lung Center · DEUniversidade Nova de Lisboa · PTUniversity of Cambridge · GBUniversity of Lisbon · PTWellcome Sanger Institute · GBIndian Council of Medical Research · INLinköping University · SEMinistry of Health · SZTartu University Hospital · EEUniversity Hospital Schleswig-Holstein · DEUniversity of Otago · NZ
Funding
Medical Research Council MR/K000551/1Medical Research Council MR/M01360X/1Medical Research Council MR/N010469/1Wellcome TrustWellcome Trust 201344/Z/16/ZWellcome Trust WT098600
Abstract
A screening of more than 1,500 drug-resistant strains of
Indexed as
MutationAlanine RacemaseAntibiotics, AntitubercularBacterial ProteinsCycloserineDrug Resistance, BacterialEvolution, MolecularGene ExpressionMicrobial Sensitivity TestsMycobacterium tuberculosisPhylogenySelection, GeneticAlanine RacemaseAntibiotics, AntitubercularBacterial ProteinsCycloserinealanine racemasecycloserineMycobacterium tuberculosis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.