Evidence map›Paper›PMID 28971350›Full record

ArticleVirologica Sinica2017

Productive HBV infection of well-differentiated, hNTCP-expressing human hepatoma-derived (Huh7) cells.

Ming Zhou, Kaitao Zhao, Yongxuan Yao, Yifei Yuan, Rongjuan Pei, Yun Wang, Jizheng Chen, Xue Hu, Yuan Zhou, Xinwen Chen and 1 more

Abstract read
In one paragraph

Article in Virologica Sinica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Hepatitis B virus entry, assembly, and egress.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  2. Article
  3. All-Viruses · 2023
    Article
  4. Article
  5. Relevance of HBx for Hepatitis B Virus-Associated Pathogenesis.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Phosphodiesterase-induced cAMP degradation restricts hepatitis B virus infection.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ming ZhouState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Kaitao ZhaoState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Yongxuan YaoState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Yifei YuanState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Rongjuan PeiState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Yun WangState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Jizheng ChenState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Xue HuState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Yuan ZhouState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Xinwen ChenState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Chunchen WuState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China. wucc@wh.iov.cn.ORCID http://orcid.org/0000-0002-6888-213X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feasible and effective cell models for hepatitis B virus (HBV) infection are required for investigating the complete lifecycle of this virus, including the early steps of viral entry. Resistance to dimethyl sulfoxide/polyethylene glycol (DMSO/PEG), hNTCP expression, and a differentiated state are the limiting factors for successful HBV infection models. In the present study, we used a hepatoma cell line (Huh7D

Indexed as

Cell Line, TumorCulture MediaDimethyl SulfoxideGene ExpressionHepatitis B virusHepatocytesHumansOrganic Anion Transporters, Sodium-DependentPolyethylene GlycolsSymportersVirus CultivationCulture MediaDimethyl SulfoxideOrganic Anion Transporters, Sodium-Dependentpolyethylene glycol 8000Polyethylene Glycolssodium-bile acid cotransporterSymportersdimethyl sulfoxide (DMSO)Hepatitis B virus (HBV)Huh7Na+/taurocholate cotransporting polypeptide (NTCP)polyethylene glycol (PEG)susceptibility

Identifiers

PMID28971350
PMCPMC6702241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.