ArticleJournal of neurovirology2017
Resting-state functional magnetic resonance imaging in clade C HIV: within-group association with neurocognitive function.
Article in Journal of neurovirology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Automated diagnosis of HIV-associated neurocognitive disorders using large-scale Granger causality analysis of resting-state functional MRI.Computers in biology and medicine · 2019Trial
- Association of HIV infection and alcohol use on resting-state functional connectivity and mental health in youth living with perinatal HIV.Research square · 2026Article
- Early-stage diagnosis of HIV-associated neurocognitive disorders via multiple learning models based on resting-state functional magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
- Medial prefrontal cortex connectivity with the nucleus accumbens is related to HIV serostatus, perceptions of psychological stress, and monocyte expression of TNF-a.Brain, behavior, & immunity - health · 2024Article
- Hub disruption in HIV disease and cocaine use: A connectomics analysis of brain function.Drug and alcohol dependence · 2024Article
- Distance-specific functional connectivity strength alterations in human immunodeficiency virus asymptomatic neurocognitive impairment patients: a cross-sectional study.Quantitative imaging in medicine and surgery · 2024Article
- Movement-related beta and gamma oscillations indicate parallels and disparities between Alzheimer's disease and HIV-associated neurocognitive disorder.Neurobiology of disease · 2023Article
- Reversible large-scale network disruption correlates with neurocognitive improvement in HIV-associated minor neurocognitive disorder with combined anti-retroviral therapy intensification: a prospective longitudinal resting-state functional magnetic resonance imaging study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- The default mode network is affected in the early stage of simian immunodeficiency virus infection: a longitudinal study.Neural regeneration research · 2023Article
- Cortico-striatal networking deficits associated with advanced HIV disease and cocaine use.Journal of neurovirology · 2023Article
- The Individualized Prediction of Neurocognitive Function in People Living With HIV Based on Clinical and Multimodal Connectome Data.IEEE journal of biomedical and health informatics · 2023Article
- Synergistic effects of HIV and marijuana use on functional brain network organization.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- Whole-brain computational modeling reveals disruption of microscale brain dynamics in HIV infected individuals.Human brain mapping · 2021Article
- The Relationship Between Central Auditory Tests and Neurocognitive Domains in Adults Living With HIV.Frontiers in neuroscience · 2021Article
- Deep Phenotyping of HIV Neurocognitive Complications Among Individuals Residing in High-Income Countries.Current topics in behavioral neurosciences · 2021Article
- Detecting cognitive impairment in HIV-infected individuals using mutual connectivity analysis of resting state functional MRI.Journal of neurovirology · 2020Article
- Use of Neuroimaging to Inform Optimal Neurocognitive Criteria for Detecting HIV-Associated Brain Abnormalities.Journal of the International Neuropsychological Society : JINS · 2020Article
- Aging, comorbidities, and the importance of finding biomarkers for HIV-associated neurocognitive disorders.Journal of neurovirology · 2019Review
- Diagnostic and prognostic biomarkers for HAND.Journal of neurovirology · 2019Review
- Low-frequency fluctuation characteristics in rhesus macaques with SIV infection: a resting-state fMRI study.Journal of neurovirology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Neuroimaging abnormalities are common in chronically infected HIV-positive individuals. The majority of studies have focused on structural or functional brain outcomes in samples infected with clade B HIV. While preliminary work reveals a similar structural imaging phenotype in patients infected with clade C HIV, no study has examined functional connectivity (FC) using resting-state functional magnetic resonance imaging (rs-fMRI) in clade C HIV. In particular, we were interested to explore HIV-only effects on neurocognitive function using associations with rs-fMRI. In the present study, 56 treatment-naïve, clade C HIV-infected participants (age 32.27 ± 5.53 years, education 10.02 ± 1.72 years, 46 female) underwent rs-fMRI and cognitive testing. Individual resting-state networks were correlated with global deficit scores (GDS) in order to explore associations between them within an HIV-positive sample. Results revealed ten regions in six resting-state networks where FC inversely correlated with GDS scores (worse performance). The networks affected included three independent attention networks: the default mode network (DMN), sensorimotor network, and basal ganglia. Connectivity in these regions did not correlate with plasma viral load or CD4 cell count. The design of this study is unique and has not been previously reported in clade B. The abnormalities related to neurocognitive performance reported in this study of clade C may reflect late disease stage and/or unique host/viral dynamics. Longitudinal studies will help to clarify the clinical significance of resting-state alterations in clade C HIV.
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Registered trials
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