Evidence map›Paper›PMID 28971330›Full record

ArticleMolecular imaging and biology2018

3'-Deoxy-3'-[

Sonja Schelhaas, Kathrin Heinzmann, Davina J Honess, Donna-Michelle Smith, Heather Keen, Sandra Heskamp, Timothy H Witney, Laurent Besret, Sabrina Doblas, John R Griffiths and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  2. Exploring Solvent Effects in the Radiosynthesis ofACS pharmacology & translational science · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 4 countries.

Sonja SchelhaasEuropean Institute for Molecular Imaging (EIMI), Westfälische Wilhelms-Universität (WWU) Münster, Waldeyerstr. 15, 48149, Münster, Germany.
Kathrin HeinzmannCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Davina J HonessCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Donna-Michelle SmithCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Heather KeenPHB Imaging Group, AstraZeneca, Alderley Park, Macclesfield, UK.
Sandra HeskampDepartment of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.
Timothy H WitneyComprehensive Cancer Imaging Centre, Imperial College London, London, UK.
Laurent BesretSanofi Oncology, Vitry-sur-Seine, France.
Sabrina DoblasLBI, UMR1149-CRI, INSERM, Paris, France.
John R GriffithsCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Eric O AboagyeComprehensive Cancer Imaging Centre, Imperial College London, London, UK.
Andreas H JacobsEuropean Institute for Molecular Imaging (EIMI), Westfälische Wilhelms-Universität (WWU) Münster, Waldeyerstr. 15, 48149, Münster, Germany. ahjacobs@uni-muenster.de.
Imperial College London · GBCancer Research UK · GBAstraZeneca (United Kingdom) · GBInserm · FRJohanniter-Krankenhaus Bonn · DERadboud University Medical Center · NLSanofi (France) · FRUniversity of Cambridge · GBUniversity of Münster · DE

Funding

Cancer Research UK 11562
6 · The paper itself

Abstract

purposeWe recently reported that high thymidine phosphorylase (TP) expression is accompanied by low tumor thymidine concentration and high 3'-deoxy-3'-[ PROCEDURES: Lysates from n = 15 different tumor models originating from n = 6 institutions were tested for TP and thymidylate synthase (TS) expression using western blots. Results were correlated to [

resultsExpression of TP correlated positively with [

conclusionsIn a broad range of tumors, [

Indexed as

AnimalsDideoxynucleosidesHumansMiceNeoplasms, ExperimentalThymidineThymidine PhosphorylasealovudineDideoxynucleosidesThymidineThymidine Phosphorylase[18F]FLTOncologyPETThymidine phosphorylase

Identifiers

PMID28971330
OpenAlexW2762342537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.