ArticleVirchows Archiv : an international journal of pathology2018
Placental pathology varies in hypertensive conditions of pregnancy.
Article in Virchows Archiv : an international journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Optimal blood pressure target to prevent severe hypertension in pregnancy: A systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Pooled it
- Placental hypoplasia and vascular malperfusion are associated with reduced brain volumes in fetal congenital heart disease.Pediatric research · 2026Article
- The impact of folic acid supplementation in early to mid-pregnancy on the risk of hypertensive disorders of pregnancy: the Japan environment and children's study.BMC pregnancy and childbirth · 2026Article
- Clinicopathologic correlation and interdependence of basic patterns of placental injury.Virchows Archiv : an international journal of pathology · 2025Observational
- Evidence that atherosis of the spiral artery represents atherosclerotic lesions similar to those of native and transplant-induced atherosclerosis: implications for understanding the pathophysiology of obstetrical syndromes and long-term cardiovascular risk.American journal of obstetrics and gynecology · 2025Article
- The associations of maternal serum ferritin levels with hypertensive disorders of pregnancy: a longitudinal cohort study.Frontiers in nutrition · 2025Article
- Article
- Gestational Age, Infection, and Suboptimal Maternal Prepregnancy BMI Independently Associate with Placental Histopathology in a Cohort of Pregnancies without Major Maternal Comorbidities.Journal of clinical medicine · 2024Article
- Preeclampsia Associated Differences in the Placenta, Fetal Brain, and Maternal Heart Can Be Demonstrated Antenatally: An Observational Cohort Study Using MRI.Hypertension (Dallas, Tex. : 1979) · 2024Observational
- Association of hypertensive disorder of pregnancy with necrotizing enterocolitis in very preterm infants: A retrospective cohort study.PloS one · 2024Article
- Article
- Placental pathology in perinatal asphyxia: a case-control study.Frontiers in clinical diabetes and healthcare · 2023Article
- Low-dose aspirin therapy improves decidual arteriopathy in pregnant women with a history of preeclampsia.Virchows Archiv : an international journal of pathology · 2022Article
- Hypertensive disorders of pregnancy: definition, management, and out-of-office blood pressure measurement.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- Placental Maternal Vascular Malperfusion is Associated with Prepregnancy and Early Pregnancy Maternal Cardiovascular and Thrombotic Profiles.Reproductive medicine (Basel, Switzerland) · 2022Article
- The association between fetal fraction and pregnancy-related complications among Chinese population.PloS one · 2022Article
- Proportionality of Clinical Outcome and Placental Changes to the Increasing Severity of Maternal Hypertension- An Observational Study.Turk patoloji dergisi · 2021Observational
- Examining the Relationship Between Gastroschisis and Placental Fetal Vascular Malperfusion.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology SocietyArticle
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1 author at 1 institution in 1 country.
Funding
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Abstract
This study was a comprehensive analysis of placental phenotypes in hypertensive conditions of pregnancy, including recently described placental hypoxic lesions and lesions of shallow placentation. To this end, consecutive placentas from > 21 weeks pregnancies that were signed out by the author at 4 tertiary care centers on 3 continents were included. Twenty-four clinical and 50 placental phenotypes were studied in 6 groups and statistically compared: 91 cases of gestational hypertension, 187 cases of mild preeclampsia, 211 cases of severe preeclampsia, 84 cases of HELLP or eclampsia, 127 cases of chronic hypertension, and 55 cases of preeclampsia superimposed on chronic hypertension. Twenty percent of the placental and clinical phenotypes were statistically significantly different between the groups. Gestational hypertension and chronic hypertension distinguished themselves by having the highest perinatal mortality, lowest cesarean section rates, highest acute chorioamnionitis, and highest fetal vascular ectasia but conspicuously fewer differences in hypoxic and thrombotic lesions. The preeclamptic groups showed the highest rates of decidual arteriolopathy (both hypertrophic and atherosis), uterine pattern of chronic placental injury, villous infarctions, and clusters of maternal floor multinucleate trophoblasts. Based on placental pathology, severe preeclampsia may be more of a placental disease and mild preeclampsia more of a maternal disease; however, the significant overlap among the groups does not make the difference absolute, and the occurrence of decidual arteriolopathy in gestational hypertension and chronic hypertension may indicate that the conditions could be regarded as "occult preeclampsia."
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