ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017
Gender-specific association between dietary acid load and total lean body mass and its dependency on protein intake in seniors.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Association between dietary acid load and risk of osteoporotic fractures in adults: a systematic review and meta-analysis of observational studies.BMC musculoskeletal disorders · 2025Pooled it
- Metabolic syndrome in relation to dietary acid load: a dose-response meta-analysis of observational studies.Frontiers in nutrition · 2023Pooled it
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- Association of dietary acid load with diabetes and glucose metabolism index in Chinese adults: a cross-sectional study.Food & nutrition research · 2026Article
- Can malnutrition, dietary habits, and diet quality be determinant factors in frailty, sarcopenia, low physical function, and depression in older adults?BMC geriatrics · 2025Article
- Association of dietary acid load with abdominal adiposity based on traditional and novel anthropometric indices.Journal of health, population, and nutrition · 2025Article
- Survey on female college students' perception of body shape and diet status.Journal of exercise rehabilitation · 2025Article
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- High dietary acid load increases the risk of disability in women aged 75 years and older: A community-based cohort study.The Journal of frailty & aging · 2025Article
- Quality attributes, antioxidant activity and color profile of orange-fleshed sweet potato grown in Vietnam.Food chemistry: X · 2024Article
- Association Between Dietary Acid Load and Grip Strength in Adults 50 Years and Older: A Cross-Sectional Study.Calcified tissue international · 2024Article
- Dietary acid load and risk of diminished ovarian reserve: a case-control study.Reproductive biology and endocrinology : RB&E · 2024Article
- Summatory Effects of Anaerobic Exercise and a 'Westernized Athletic Diet' on Gut Dysbiosis and Chronic Low-Grade Metabolic Acidosis.Microorganisms · 2024Review
- Article
- The association of dietary acid load (DAL) with estimated skeletal muscle mass and bone mineral content: a cross-sectional study.BMC nutrition · 2023Article
- The association between dietary acid load and body composition in physical education students aged 18-25 years.Journal of health, population, and nutrition · 2022Article
- Association between dietary acid load and metabolic health status in overweight and obese adolescents.Scientific reports · 2022Article
- Observational and clinical evidence that plant-based nutrition reduces dietary acid load.Journal of nutritional science · 2022Review
- Associations between dietary acid load and obesity among Iranian women.Journal of cardiovascular and thoracic research · 2021Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Diet-related mild metabolic acidosis may play a role in the development of sarcopenia. We investigated the relationship between dietary acid load and total lean body mass in male and female seniors age ≥ 60 years. We found that a more alkaline diet was associated with a higher %TLM only among senior women.
introductionThe aim of this study was to determine if dietary acid load is associated with total lean body mass in male and female seniors age ≥ 60 years.
methodsWe investigated 243 seniors (mean age 70.3 ± 6.3; 53% women) age ≥ 60 years who participated in the baseline assessment of a clinical trial on vitamin D treatment and rehabilitation after unilateral knee replacement due to severe knee osteoarthritis. The potential renal acid load (PRAL) was assessed based on individual nutrient intakes derived from a food frequency questionnaire. Body composition including percentage of total lean body mass (%TLM) was determined using dual-energy X-ray absorptiometry. Cross-sectional analyses were performed for men and women separately using multivariable regression models controlling for age, physical activity, smoking status, protein intake (g/kg BW per day), energy intake (kcal), and serum 25-hydroxyvitamin D concentration. We included a pre-defined subgroup analysis by protein intake (< 1 g/kg BW day, > 1 g/kg BW day) and by age group (< 70 years, ≥ 70 years).
resultsAdjusted %TLM decreased significantly across PRAL quartiles only among women (P
conclusionThe association between dietary acid load and %TLM seems to be gender-specific, with a negative impact on total lean mass only among senior women. Therefore, an alkaline diet may be beneficial for preserving total lean mass in senior women, especially in those with low protein intake.
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